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Project Summary AbstractFecal incontinenceFIthe involuntary soiling of various amounts of liquid and solid stoolis often devastating from a socialpsychologicaland hygiene perspectiveMen and women suffer from FI equally with a range ofin people agedyearsThe prevalence increases to overin people older thanyearsFI may result from an isolated or combined loss of smooth muscle functionIASskeletal muscl ...

ABSTRACTRedbud Labs proposes to develop a low costintegrated microfluidic system to purify and concentrate pathogens directly frommL of whole bloodwith the goal of improving the sensitivity of downstream blood culture and molecular diagnostic assays used in sepsis diagnosis and treatmentPhase I studies have demonstrated that our technologybased on actuated surface attached postsASAPscan achieve hi ...

PROJECT SUMMARYNucleosomesNucsare the repeating units of chromatinmade up of DNA wrapped around a histone octamerChanges in chromatin structurefunction can dramatically impact downstream gene expression and cellular physiologydriving oncogenic reprogramming and cancer progressionThis epigenetic regulation of chromatin is controlled by two major modificationshistone post translational modifications ...

PUBLIC ABSTRACT This projectin response to announcement HLSdescribes a development program for CARSKNKDCCARa synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapiesfor the treatment of pulmonary hypertensionPHPH is a disorder of elevated pulmonary vascular resistance characterized by progressive thickeni ...

PROJECT SUMMARYABSTRACTAging and diabetesas well as many neurological conditionssuch as multiple sclerosisParkinsonandapos s diseasespina bifidastrokeand spinal cord injurySCIcan result in loss of voluntary voiding of urine and require intermittent bladder catheterization for voidingCatheter use is associated with increased incidence of health problemspredominately repeated urinary tract infection ...

ImmuNext has defined an anti MCTmonoclonal antibodymAbthat will be developed for the treatment of human autoimmune diseaseThe membrane monocarboxylate nutrient transporter SLCAMCTis a multi pass transmembrane protein responsible for the facilitated transport of critical metabolitesincluding products of glycolysislactatepyruvate and ketonesOur strong preliminary data support the tenet that mAbs tha ...

Project SummaryAlthough widespread screening by mammography has successfully cut mortality from breast cancerBCathe exquisite sensitivity of the technique results in a startling number offalse positivesOf approximatelymillion women who receive a positive mammogram each yearfewer thanwill be diagnosed with BCaCumulativelythe economic cost of followup diagnostics to resolve falsepositive mammograms ...

PROJECT SUMMARYEpiCypher is pioneering the commercial development of fully defined recombinantsemi synthetic nucleosomes carrying specific histone post translational modificationsPTMstermed designer nucleosomes or dNucsTMfor epigenetics researchWe currently use native chemical ligationNCLto generate modified histones for dNuc assemblyand have developed proprietary methods to efficiently manufactur ...

CivaTech Oncology s mission is to provide improved radiation therapy directly to localized tumorsThe Company has developed a novelpolymer encapsulatedmembrane like radiation source that emits radiation on only one side of the devicethe CivaSheetThis directional source is compatible with open and minimally invasive surgical techniques and has FDA clearance to be used as primary or combined cancer t ...

PROJECT SUMMARY Advanced Chemotherapy TechnologiesACThas developed a proprietary implantable iontophoretic device that facilitates the infusion of chemotherapy agents directly into a cancer tumorminimizing toxic exposure to the vascular system and other organsACT is focusing specifically on treating pancreatic cancer with gemcitabine for this proposalPancreatic cancer has a five year survival rate ...