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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. DRIVEN: Accelerating Medical Entrepreneurship in the Northeast

    SBC: CELDARA MEDICAL, LLC            Topic: 500

    Project Summary This project describes the formationlaunch and operation of the DRIVEN Accelerator Hubwith the express goal of reducing morbidity and mortality by increasing the number of medical entrepreneurs and their level of competencyThe Hub is focused on the Northeast andin collaboration with similar Hubswill contribute nationwideIt willin a facilecompleteand accessible wayprovide the knowle ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections

    SBC: Zymeron Corporation            Topic: NIAID

    CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. TOPIC 343: NEUROPSYCHOLOGICAL ASSESSMENT SYSTEM FOR CANCER PATIENTS

    SBC: CREARE LLC            Topic: NCI

    Cognitive decline is a major quality of life concern for many cancer survivorsThevarious available treatments affect individuals differentlyand research has unfortunately provided little guidance on how specific treatments impact neurocognitive functionTo help researchers fill this information gap and ultimately provide guidance to doctors and patientsa neuropsychological assessment system that is ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. AUTOMATED PLATE TRANSPORT SYSTEM

    SBC: CREARE LLC            Topic: NIDA

    High throughput screeningHTShas emerged as a leading method of drug discovery and development in the pharmaceutical industryacademiaand at the NIH National Center for Advancing Translational SciencesNCATSHTS relies on the ability to rapidly screen tens of thousands of compounds to identify the most promising drugs and their dose response curvesHTS isof necessityhighly automated and demands mechani ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a New Carbohydrate-based Anticoagulant Drug

    SBC: Glycan Therapeutics LLC            Topic: NHLBI

    Low molecular weight heparinsLMWHsare partially depolymerized natural products of heparinwhich are isolated from porcine intestineA worldwide distribution of contaminated heparin inwas associated withdeaths in the USThis crisis revealed the vulnerability of the LMWH supply chainLMWHs are complex mixtureshaving average molecular masses ofDaltonscorresponding tosaccharide unitsThe efficient preparat ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Whole-organ bioreactor with integrated nondestructive 3D molecular imaging

    SBC: Sonovol, Inc.            Topic: NHLBI

    Abstract SignificanceDonor tissue shortage remains a critical problem in lung transplantationRecent advances in tissue engineering have allowed for the possibility of generating bioengineered lungs from decellularized organ scaffoldsThese scaffoldscreated from the donor s tissuebecome functionalized after recellularization with a patient s own cellsHowevertranslation of whole lung decell recell te ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy Verification

    SBC: DoseOptics LLC            Topic: 102

    Abstract Optical Cherenkov video imaging of body anatomy and dose delivery can be used now to map out radiotherapy beam incidence upon the patient tissuedirectly visualizing the radiation dose deposition on the patient in real timeThis could serve as a non contact workflow tool for verification for daily fractionated radiation therapyallowing capture of all treatmentsall the timeDoseOptics has dev ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. New Class of Bright, Sharp, Tunable Near-Infrared Fluorophores for Flow Cytometry

    SBC: Nirvana Sciences, Inc.            Topic: NIAID

    Abstract Polychromatic flow cytometryFCis one of the most powerful analytical techniques routinely used by both basic research and clinical diagnostics laboratories for the immunological categorization of cellsDyes used for FC typically exhibit broad fluorescent emission bands with full width at half maximumfwhmvalues ofnmThis limits the maximum number of dyesand thus the number of cell biomarkers ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Multiplex Platform for Point-of-Care Newborn Screening of Hyperbilirubinemia

    SBC: Baebies, Inc.            Topic: NICHD

    ABSTRACT Multiplex Platform for Point of Care Newborn Screening of HyperbilirubinemiaSBIR Phase IIBHyperbilirubinemiajaundiceaffects more than half of all newborns and is typically benign if identified and treated promptlyWithout proper treatmenthigh bilirubin leads to serious neurological dysfunction including neuro motorauditoryspeechcognitionand language disturbancesRapid identification of newb ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Tomographic Nanoscopy for Pathogen Identification

    SBC: SOLID STATE SCIENTIFIC CORPORATION            Topic: CBD171003

    This Phase II effort prototypes a minimal volume microscope designed to allow for a 2-D digital holographic imaging concurrent with field of view spectral content at video frame rates. The use of a laser driven IR dual beam frequency comb, coincident with the optical beam path required for a digital holographic image, will allow rapid acquisition of both the spatial and the spectral content associ ...

    SBIR Phase II 2019 Department of DefenseOffice for Chemical and Biological Defense
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