Award Data

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DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

DESCRIPTION (provided by applicant): Founded in 1998, Altea Therapeutics is developing its PassPort(tm) system to deliver proteins and peptides, small-molecule drugs, genes and vaccines from a skin patch, eliminating the need for invasive needle injection. This breakthrough technology, currently undergoing Phase 1 clinical trials for basal insulin delivery, revolutionizes the way in which medicine ...

By continuing teaming up with one of the most reputable university teams in THz science and technology, ArkLight proposes to carry out the tasks set for a Phase-II program following our success in Phase I. We are aimed at the further development of novel spectrometers to analyze chemicals in the vapor phase based on accurate measurements of the emission and absorption spectra due to the molecular ...

CONSIDERABLE EVIDENCE EXISTS THAT ANALYSIS OF THE ELECTRO- CARDIOGRAM OVER EXTENDED PERIODS OF TIME PROVIDES CLINICALLYSIGNIFICANT INFORMATION IMPORTANT IN THE DIAGNOSIS AND TREATMENT OF CARDIAN DISEASE. AVAILABLE AMBULATORY MONITOR-ING DEVICES ARE ADEQUATE FOR 24-HOUR PERIODS; LIMITATIONS ARE EVIDENT WHEN LONGER PERIODS ARE REQUIRED. THE PROJECT WILL ESTABLISH THE FEASIBILITY OF BIOLOGICAL DATA A ...

DESCRIPTION (provided by applicant): This Phase II SBIR project describes a novel method to create transgenic poultry that will produce biopharmaceutical proteins in their eggs. Chickens are able to produce large amounts of protein in their eggs at relatively low cost. We seek to harness this capability to synthesize pharmaceutical proteins, such as humanized monoclonal antibodies, that are neede ...

DESCRIPTION (provided by applicant): There is growing recognition that surgical repair of the heart is most likely to be successful in infancy (when there is dramatic capacity for growth and remodeling). For a subset of patients, the optimal time for intervention is prior to birth. Current prenatal cardiac intervention (PCI) procedures clearly have technical limitations in both fetal visualizat ...

DESCRIPTION (provided by applicant): The overall objective of the proposed work is to reduce the cost of accelerator produced F-18 radiopharmaceuticals used in Positron Emission Tomography (PET), a Medicare-reimbursed nuclear medicine metabolic imaging modality used to diagnose, stage, and restage ten cancer indications. Annual PET scans (350,000+) are rapidly increasing, but CMS reimbursement ...

DESCRIPTION (provided by applicant): The overall objective of the proposed work is to reduce the cost of accelerator produced F-18 radiopharmaceuticals used in Positron Emission Tomography (PET), a Medicare-reimbursed nuclear medicine metabolic imaging modality used to diagnose, stage, and restage ten cancer indications. Annual PET scans (350,000+) are rapidly increasing, but CMS reimbursement ...

DESCRIPTION (provided by applicant): Remarkable progress has been made over the last decade on ventricular assist devices for adult heart failure patients. Thousands of patients' lives have been saved each year. Unfortunately, similar devices are not yet available in the US for pediatric heart patients. Development of such devices has been impeded by the fact that the pediatric market size is t ...