Award Data

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

Effective collective protection fabrics must have a reliable closure system. During our Phase I Work Plan, Sigma-K began developing a Hermetic Textile Closure Hardware (HATCH) system. The HATCH combines both a magnetic and geometric self locking mechanism that will provide a hermetic seal when closed. Our current Phase I successes include developing self closing samples that can provide a hermetic ...

In Phase I, Nomadics demonstrated that a novel chemical weapon indicating chromophore (CWIC) developed by Professor Tim Swager at MIT will allow equipment to be quickly and easily examined to show any areas of contamination, making targeted decontamination manageable. When exposed to CW agent simulants, CWICs react to become fluorescent under UV stimulation. In the first phase, we implemented a s ...

The current methodology for testing the penetration resistance of textile materials to various chemical agents has a number of drawbacks, including significant uncertainties in the resulting data, inefficiency and expense, risk to test personnel, and limited range of test conditions. The objective of the proposed work is to apply unique computer models for textiles with accompanying experimental ...

By continuing teaming up with one of the most reputable university teams in THz science and technology, ArkLight proposes to carry out the tasks set for a Phase-II program following our success in Phase I. We are aimed at the further development of novel spectrometers to analyze chemicals in the vapor phase based on accurate measurements of the emission and absorption spectra due to the molecular ...

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DESCRIPTION (provided by applicant): Cloning of hot and cold thermal receptors has advanced the understanding of the molecular basis of thermal sensation. Two (2) important remaining questions to be addressed are the identification of additional thermal receptor genes and the elucidation of the mechanism(s) that enable the receptor proteins to alter gating properties in response to changes in temp ...

MOTOR EVENT FREQUENCY RECORDING, ACTIGRAPHY, IS A TECHNOLOGY USEFUL IN STUDIES OF SLEEP DISORDERS, CIRCADIAN FUNCTION, ACTIVITY PATTERNS OF ADULTS AND INFANTS, AND DEPRESSIVE DISORDERS. WIDESPREAD UTILIZATION OF THIS MONITORING TECHNOLOGY IN HEALTH APPLICATIONS HAS BEEN DELAYED BY THE LACK OF AN AFFORDABLE ACTIVITY MONITORING INSTRUMENT AND INTEGRATED SYSTEM FOR DATA MANAGEMENT, ANALYSIS, AND PRES ...

OUR LONG-TERM AIM IS TO DEVELOP A GRAM-POSITIVE ORGANISM FORTHE EXPRESSION AND SECRETION OF MEDICALLY AND INDUSTRIALLY USEFUL PROTEINS. ONE MAJOR OBSTACLE TO THE SUCCESSFUL DEVELOPMENT OF SUCH A SYSTEM IS THE PROTEOLYTIC DEGRADATION OF SECRETED PRODUCTS. SITE-DIRECTED DELETION MUTATIONS CONSTRUCTED IN VITRO HAVE ELIMINATED THE TWO MAJOR EXTRACELLULAR PROTEASES OF B. SUBTILIS. ALTHOUGH SIGNIFICANTL ...

CONSIDERABLE EVIDENCE EXISTS THAT ANALYSIS OF THE ELECTRO- CARDIOGRAM OVER EXTENDED PERIODS OF TIME PROVIDES CLINICALLYSIGNIFICANT INFORMATION IMPORTANT IN THE DIAGNOSIS AND TREATMENT OF CARDIAN DISEASE. AVAILABLE AMBULATORY MONITOR-ING DEVICES ARE ADEQUATE FOR 24-HOUR PERIODS; LIMITATIONS ARE EVIDENT WHEN LONGER PERIODS ARE REQUIRED. THE PROJECT WILL ESTABLISH THE FEASIBILITY OF BIOLOGICAL DATA A ...