Award Data

In this Phase II program we will build on the promising Phase I results and further develop, optimize and integrate self-healing coatings/membranes into Chemical/Biological (CB) protective clothing to enable autonomous and rapid self-healing of cuts/tears/punctures and provide continuous protection to the warfighters. Current CB garment systems use a layer of absorptive carbon or selectively perm ...

Hook and loop closures in Army uniforms have been identified as the critical sources of leaks in protective clothing/equipment, which limits the overall protective capability of the ensemble. We demonstrated during Phase I of this project that we can design and fabricate hybrid closure systems which incorporate areas of microfiber adhesive arrays inspired by the foot-hairs found on geckos which ha ...

Elevated levels of human butyrylcholinesterase (hBuChE) confer protection from chemical warfare nerve agents and other organophosphorous chemicals. As a prophylactic, the key to enabling this protection is the ability to maintain elevated concentrations of hBuChE in the plasma for days or weeks. Thus far, plasma-derived hBuChE and PEGylated recombinant forms of BuChE (rBuChE) have been tested in ...

Interfaces on existing military chemical/biological protection garments are not designed to fully eliminate macroscopic and microscopic air gaps at folds, fabric surfaces, or hook-and-loop closures, and thus do not provide a hermetic barrier against exposure. Creare proposes to develop a hermetic garment closure system that seals macroscopic and microscopic gaps at interfaces and closures and pro ...

The overall goal of the SBIR Phase II program is development, fabrication, and demonstration of a fully integrated graphene-based sensor capable of detection of different types of chemical agents in the vapor phase with better than parts per billion (ppb) sensitivity and a high degree of specificity. It should also exhibit a reversible function of the sensing element. The program will synergistica ...

Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability. Extend Biosciences is developing proprietary carrier molecules that allow proteins to access an intrinsic transport pathway for efficient delivery to the vascular space and then maintain a sustained presence in circulation. This novel technology would be of partic ...

Chemical, biological, or toxin attacks in military and civilian settings are a serious and growing concern. Standard first aid for exposure to some chemical warfare agents and toxins includes the immediate administration of relevant antidotes using an autoinjector. When an attack occurs, pre-filled autoinjectors must be immediately available and thus highly portable, and they must be suitable fo ...

Physical Sciences Inc. (PSI) proposes to utilize an innovative LWIR hyperspectral technology coupled with advanced data processing algorithms for non-contact, standoff detection of liquid/solid contaminants on surfaces. The technology will address the US Army"s need for fast, on-the-move, non-contact detection of ground contamination during reconnaissance missions. The Phase I effort demonstrated ...

Having achieved or exceeded all goals and objectives of the Phase I research program, BioScale has thus demonstrated feasibility of a multiplexed, immuno-electromechanical pathogen detection method. In Phase II, BioScale proposes to advance this research by assembling a complete assay system that integrates discrete, commercial off the shelf (COTS) sample preparation subcomponents with the propri ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...