Award Data

Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometricmeasurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed softwareapp aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D imag ...

This project is a unique metagenomic evaluation of under-studied extremophilic microbiome natural products (NPs), with the goal of discovering novel antibiotic biowarfare agent (BWA) countermeasures. A metagenomic biosynthetic gene cluster library from extremophilic sources was created, sequenced, analyzed, and exploited to produce several broad-spectrum antibiotic extracts during the Phase I effo ...

Aflatoxins B1 (AFB1) are fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk for thedevelopment of hepatocellular carcinoma. Currently, there are no known countermeasures to selectively mitigate AFB1 toxicity. To meet thischallenge, we successfully validated a Phase I proof-of-concept study to harness the microbiome extracts of scavenging ma ...

Vadum will develop Chemical, Heterogeneous sensor fusion Incident awareness Module (CHIME)asoftware module that will ingest data from a large number of asynchronous, heterogeneous and multi-tiered sensors to automate the process of estimating the source attributes of a chemical or biological release. CHIME generates estimates from a continuous stream of raw sensor data with successive estimates al ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

THE U.S. POULTRY INDUSTRY ADMINISTERS ABOUT 21 BILLION DOSE UNITS OF VACCINES YEARLY. THESE VACCINATIONS ARE GIVEN TO TO DAY-OLD BIRDS FOR SEVERAL VIRAL AND BACTERIAL DISEASES, AND SUBSEQUENT VACCINATIONS TO GROWING AND ADULT CHICKENS ANAND TURKEYS. ADDITIONALLY, 170 MILLION TURKEY EMBRYOS R RECEIVE ANTIBIOTIC TREATMENT. THE WORLDWIDE POULTRY DRUG VACCINE MARKET REPRESENTS OVER $500 MILLION PR YEA ...

Approximately 5% of hatchlings do not survive the critical post-hatch period because of limited body reserves. Many survivors exhibit stunted growth, leg problems, inefficient feed utilization, reduced disease resistance, or poor meat yield. This poult quality problem has been calculated to be worth approximately $71 million and $142 million annually to the US and global turkey industry respective ...

Cultivation of Echinacea has gained worldwide interest in recent years due to its non-specific immunomodulatory activity in humans. However, Echinacea species have not been genetically improved for medicinal use. This project is to develop genetically improved Echinacea cultivars for medicinal use. The new cultivars will produce higher yield of biomass and bioactive phytochemicals than the types c ...

The current methodology for testing the penetration resistance of textile materials to various chemical agents has a number of drawbacks, including significant uncertainties in the resulting data, inefficiency and expense, risk to test personnel, and limited range of test conditions. The objective of the proposed work is to apply unique computer models for textiles with accompanying experimental ...

Low molecular weight metabolites produced by the rust mycoparasite, Aphanocladium album, can convert infective urediniospores to non-infective teliospores. The teliospore-inducing factor (TIF) has been isolated, identified and demonstrated in proof-of concept experiments to convert infective urediniospores to non-infective teliospores of the oat rust fungus, Puccinia coronata. During Phase II, we ...