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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. An optimized NK2R agonist for 'on-demand' voiding

    SBC: Dignify Therapeutics LLC            Topic: NIA

    PROJECT SUMMARY Underactive bladderUABis a clinically important problem in the elderlyUAB is characterized by weak bladder contractions and incomplete bladder emptying that result in symptoms of voiding frequencynocturiaand incontinenceand it can lead to serious complications such as permanent bladder and kidney damageAging related UAB may affect almostof Americans overand nearly two thirds of inc ...

    SBIR Phase II 2017 Department of Health and Human Services
  2. Discovering a Disease Modifying Therapeutic to Treat Huntington's Disease

    SBC: CHAPERONE THERAPEUTICS, INC.            Topic: NIA

    Protein misfolding and aggregationleading to chronic inflammationsynaptic dysfunction and neuronal death are common hallmarks of neurodegenerative diseases including Alzheimer s diseaseADand Huntington s diseaseHDWhile overmillion Americans suffer from ADand oversuffer from HDcurrent therapies target symptoms but not the underlying pathophysiology of protein misfoldingaggregation and its downstrea ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. Cartilage Regeneration with Tunable Inflammation Resistance

    SBC: Cytex Therapeutics, Inc.            Topic: NIA

    AbstractThe repair of large cartilage lesionswhich are contraindicated for currently available firstline tissueregeneration techniquesremains a significant clinical problem with few good treatment optionsPrevious workat Cytex has focused on the development of aD microwoven textile scaffold for cartilage repairdesigned tofunction immediately after implantation while encouraging cell ingrowthprolife ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. Functional Tissue Engineering for Cartilage Repair

    SBC: Cytex Therapeutics, Inc.            Topic: NIA

    Abstract It is estimated that only aboutof young patients suffering from!activity limiting hip osteoarthritisOAchoose to undergo traditional hip replacement surgeryThis low percentage is attributed to the shortened projected lifetime of hip implants for active patients and the subsequent need for revision surgeries that are plagued with higher complication rates and overall decreased effectiveness ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Safety and Efficacy of a Titratable External Shunt

    SBC: CAMRAS VISION, INC.            Topic: W

    Glaucoma is a diverse group of chronic diseases that causes irreversible damage to the optic nerve and is a leading cause of blindness affectingmillion people worldwideIt is estimated thatinpeople who receivepropertreatment for glaucoma still experience loss of visionThe only proven method of treating glaucoma is to reduce the pressure in the eyeIntraocular PressureIOPAdvanced glaucoma must achiev ...

    SBIR Phase II 2017 Department of Health and Human Services
  6. A crosslinked cartilage-derived matrix for cartilage tissue engineering

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    Abstract OsteoarthritisOAremains a significant source of significant pain and disabilityaffecting overmillion adults with an economic burden of over $billion per year to the USJoint replacement is a well established procedurebut its finite life span makes this treatment unacceptable for younger or more active individualswho often require additional revision surgeries as they ageBoth complicated re ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of Novel Targeted Chemotherapeutics for the Treatment ofMalignant Pleural Mesothelioma

    SBC: FLAG THERAPEUTICS INC            Topic: 102

    Abstract Malignant Pleural MesotheliomaMPMis an aggressive cancer effecting the lining of the lungs and is most often caused by exposure to asbestosMPM is difficult to detect and is typically diagnosed late resulting in a median survival of just one year and ayear median survival of onlyPemetrexedPmxis the standard of care but quality of life is poor due to Pmx toxicitiesThe purpose of this Direct ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. A Bullet Proof vascular graft to prevent dialysis access cannulation injury

    SBC: Innavasc Medical, Inc.            Topic: 400

    PROJECT SUMMARY End Stage Renal DiseaseESRDis a complex disease that involves total and permanent kidney failure that affects moreindividuals in the United States aloneHemodialysis is a life sustaining therapy for patients suffering from renal failure that requires that blood be withdrawn and cycled through a dialysis machine that performs the function of the failed kidneysThis process must be rep ...

    SBIR Phase II 2017 Department of Health and Human Services
  9. Clinical evaluation of the novel, uni-directional, Pd-103 CivaSheet for Pancreatic Cancers

    SBC: CivaTech Oncology, Inc.            Topic: 102

    CivaTech Oncology s mission is to provide improved radiation therapy directly to localized tumorsThe Company has developed a novelpolymer encapsulatedmembrane like radiation source that emits radiation on only one side of the devicethe CivaSheetThis directional source is compatible with open and minimally invasive surgical techniques and has FDA clearance to be used as primary or combined cancer t ...

    SBIR Phase II 2017 Department of Health and Human Services
  10. The Impact Integrated Data System for Quality and Outcomes Tracking of Prevention Programs

    SBC: 3-C Institute for Social Development, Inc.            Topic: 104

    Abstract There has been substantial progress in developing evidence based prevention programsEBPPsfor preventing risky behaviors and promoting positive mental health outcomes for youthUnfortunatelyEBPP adoptionquality implementationlong term sustainabilityand scalability in real world service settings continues to lag far behindjeopardizing the ability to achieve the intended broad scale public im ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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