Award Data

PROJECT SUMMARY Underactive bladderUABis a clinically important problem in the elderlyUAB is characterized by weak bladder contractions and incomplete bladder emptying that result in symptoms of voiding frequencynocturiaand incontinenceand it can lead to serious complications such as permanent bladder and kidney damageAging related UAB may affect almostof Americans overand nearly two thirds of inc ...

Protein misfolding and aggregationleading to chronic inflammationsynaptic dysfunction and neuronal death are common hallmarks of neurodegenerative diseases including Alzheimer s diseaseADand Huntington s diseaseHDWhile overmillion Americans suffer from ADand oversuffer from HDcurrent therapies target symptoms but not the underlying pathophysiology of protein misfoldingaggregation and its downstrea ...

AbstractThe repair of large cartilage lesionswhich are contraindicated for currently available firstline tissueregeneration techniquesremains a significant clinical problem with few good treatment optionsPrevious workat Cytex has focused on the development of aD microwoven textile scaffold for cartilage repairdesigned tofunction immediately after implantation while encouraging cell ingrowthprolife ...

Abstract It is estimated that only aboutof young patients suffering from!activity limiting hip osteoarthritisOAchoose to undergo traditional hip replacement surgeryThis low percentage is attributed to the shortened projected lifetime of hip implants for active patients and the subsequent need for revision surgeries that are plagued with higher complication rates and overall decreased effectiveness ...

Glaucoma is a diverse group of chronic diseases that causes irreversible damage to the optic nerve and is a leading cause of blindness affectingmillion people worldwideIt is estimated thatinpeople who receivepropertreatment for glaucoma still experience loss of visionThe only proven method of treating glaucoma is to reduce the pressure in the eyeIntraocular PressureIOPAdvanced glaucoma must achiev ...

Abstract OsteoarthritisOAremains a significant source of significant pain and disabilityaffecting overmillion adults with an economic burden of over $billion per year to the USJoint replacement is a well established procedurebut its finite life span makes this treatment unacceptable for younger or more active individualswho often require additional revision surgeries as they ageBoth complicated re ...

Abstract Malignant Pleural MesotheliomaMPMis an aggressive cancer effecting the lining of the lungs and is most often caused by exposure to asbestosMPM is difficult to detect and is typically diagnosed late resulting in a median survival of just one year and ayear median survival of onlyPemetrexedPmxis the standard of care but quality of life is poor due to Pmx toxicitiesThe purpose of this Direct ...

PROJECT SUMMARY End Stage Renal DiseaseESRDis a complex disease that involves total and permanent kidney failure that affects moreindividuals in the United States aloneHemodialysis is a life sustaining therapy for patients suffering from renal failure that requires that blood be withdrawn and cycled through a dialysis machine that performs the function of the failed kidneysThis process must be rep ...

CivaTech Oncology s mission is to provide improved radiation therapy directly to localized tumorsThe Company has developed a novelpolymer encapsulatedmembrane like radiation source that emits radiation on only one side of the devicethe CivaSheetThis directional source is compatible with open and minimally invasive surgical techniques and has FDA clearance to be used as primary or combined cancer t ...

Abstract There has been substantial progress in developing evidence based prevention programsEBPPsfor preventing risky behaviors and promoting positive mental health outcomes for youthUnfortunatelyEBPP adoptionquality implementationlong term sustainabilityand scalability in real world service settings continues to lag far behindjeopardizing the ability to achieve the intended broad scale public im ...