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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Accelerated discovery of methylation targeted therapeutic development

    SBC: Epicypher, Inc.            Topic: 102

    PROJECT SUMMARYNucleosomesNucsare the repeating units of chromatinmade up of DNA wrapped around a histone octamerChanges in chromatin structurefunction can dramatically impact downstream gene expression and cellular physiologydriving oncogenic reprogramming and cancer progressionThis epigenetic regulation of chromatin is controlled by two major modificationshistone post translational modifications ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Adaptable Pediatric Neurocognitive Assessment

    SBC: CREARE LLC            Topic: 103

    PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Advanced Indoor Navigation Aid for Blind and Visually-Impaired Individuals in Unfamiliar Spaces

    SBC: VORTANT TECHNOLOGIES, LLC            Topic: N

    Project Summary Abstract Confusionbeing lostand losing track of oneandapos s orientation within large or unfamiliar indoor spacesthese are some of the biggest challenges facing people with visual disabilitiesSince GPS typically doesnandapos t work indoorsand isnandapos t fine grained enough anywayindividuals who cannot readily access visual information are at a significant disadvantageand many bli ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A Low-Cost Platform for Routine High-Accuracy Sizing of Nucleic Acid Samples with 100 bp- 100 Mbp Dynamic Range

    SBC: Genturi Inc.            Topic: 172

    The goal of this project is to develop a microand nanofluidic DNA sizing platform with a sensitivityspeedand dynamic range that is unmatched by current sizing technologiesWe find that fluorescence burst analysis of individual DNA molecules transported through sub micrometer scale channels provides accurate and precise sizing of fragments betweenbp ands of MbpIn this singlemolecule sizing platformu ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. An Aerosol Device for Measles Vaccination (B)

    SBC: CREARE LLC            Topic: NA

    N/A

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  6. Analysis Tools for Detection and Diagnosis of Biological Threats

    SBC: ALPHA-GAMMA TECHNOLOGIES, INC.            Topic: CBD04113

    DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
  7. An Integrative Approach to Control Group Creation for Prevention Research

    SBC: Prevention Strategies, LLC            Topic: 550

    PROJECT ABSTRACTThe goal of this Phase II SBIR project is to develop a method for creating algorithmically generated control groupsvirtual controlsThese will be composed of synthetic cases that have two characteristicspretest similarity to whatever prevention treatment group may present itself andpatterns of change over time that closely mimic the normal course of alcohol and drug use developmentT ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. A novel class of anti-acne therapeutics

    SBC: Verge Therapeutics            Topic: NIAMS

    Acne Vulgaris is a common skin disorder that affectsof the populationtypically teenagers and young adultsOvermillion people in the US are affected by acne generating a $billion market for acne treatmentsof which is derived from prescription medicationsAlthough acne is not a life threatening conditionit still has a high psychosocial impact resulting in depressionanxietyangersuicidal thoughtsphysica ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. A Novel Hernia Mesh to Improve Anchor Point Fixation and Prevent Hernia Formation

    SBC: Deep Blue Medical Advances, Inc.            Topic: 300

    Two million laparotomies are performed annually in the U Swith ventral hernia being a frequent complication inof patients and costing as much as $billion annuallyThe ten year ventral hernia recurrence rate is reportedlywithout hernia mesh andwhen a mesh is added to the repair and these numbers underestimate recurrence rates in the rapidly growing morbidly obese population in the USIn Junein the La ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. A novel protein engineering tool for rapid manufacturing of designer nucleosomes

    SBC: Epicypher, Inc.            Topic: 103

    PROJECT SUMMARYEpiCypher is pioneering the commercial development of fully defined recombinantsemi synthetic nucleosomes carrying specific histone post translational modificationsPTMstermed designer nucleosomes or dNucsTMfor epigenetics researchWe currently use native chemical ligationNCLto generate modified histones for dNuc assemblyand have developed proprietary methods to efficiently manufactur ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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