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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Accelerated discovery of methylation targeted therapeutic development

    SBC: Epicypher, Inc.            Topic: 102

    PROJECT SUMMARYNucleosomesNucsare the repeating units of chromatinmade up of DNA wrapped around a histone octamerChanges in chromatin structurefunction can dramatically impact downstream gene expression and cellular physiologydriving oncogenic reprogramming and cancer progressionThis epigenetic regulation of chromatin is controlled by two major modificationshistone post translational modifications ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Adaptable Pediatric Neurocognitive Assessment

    SBC: CREARE LLC            Topic: 103

    PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. ADAPTING EXISTING CURRICULA FOR PROMOTING SOCIAL AND ADA

    SBC: THREE C INSTITUTE FOR SOCIAL DEVELOPMT            Topic: N/A

    Location 1903 N HARRISON AVE, STE 101 CARY, NC 27513 United States N44MH0664102C $365 147.00 2 005 ADAPTING EXISTING CURRICULA FOR PROMOTING SOCIAL AND ADA Department of Health and Human Services National Institutes of Health SBIR PHS2006-1 THREE C INSTIT ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Additional costs related to formulation, chronic tox and general development of PTI-125

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIA

    Project Summary Abstract PTIis a novel small molecule AD therapeutic candidate with a novel target and mechanism of actionPTIbinds and reverses an altered conformation of the scaffolding protein filamin AFLNAto prevent Aandapos s tight binding to and toxic signaling via thenicotinic acetylcholine receptornAChRas well as Aandapos s aberrant activation of toll like receptorTLRHenceby restoring FLNAa ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. ADD Regulatory Compliance and Cost (Rev A)

    SBC: Mealtime Partners, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to reduce the cost, complete government regulatory compliance tests, obtain FDA classification, and establish FDA quality system standards for producing a new and innovative assistive technology (AT) that permits individuals, who otherwise cannot feed themselves, to do so without assistance from another person after they are pr ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  6. Advanced Indoor Navigation Aid for Blind and Visually-Impaired Individuals in Unfamiliar Spaces

    SBC: VORTANT TECHNOLOGIES, LLC            Topic: N

    Project Summary Abstract Confusionbeing lostand losing track of oneandapos s orientation within large or unfamiliar indoor spacesthese are some of the biggest challenges facing people with visual disabilitiesSince GPS typically doesnandapos t work indoorsand isnandapos t fine grained enough anywayindividuals who cannot readily access visual information are at a significant disadvantageand many bli ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Advanced Technology for Administration of the Teen-ASI

    SBC: Health Outcomes Inc            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to conduct a clinical trial using a suite of web-based software products as well as a web portal that will help with standardized assessment, treatment planning, referral, and outcomes tracking for adolescent substance abuse treatment. Products will include the automated Internet version of the Self- Report Teen-Addiction Severity Index (SR-T-ASI Net ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  8. All Stars Technology: Web-Based Program Enhancements

    SBC: TANGLEWOOD RESEARCH INC            Topic: N/A

    DESCRIPTION (provided by applicant): The success of research-based prevention programs depends on the degree to which they are implemented with fidelity. This Phase II project will enhance All Stars, a drug abuse prevention program, by integrating web-based and multimedia technologies. Enhancements will improve program fidelity by making the program easier to deliver. They will improve effectivene ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  9. A Low-Cost Platform for Routine High-Accuracy Sizing of Nucleic Acid Samples with 100 bp- 100 Mbp Dynamic Range

    SBC: Genturi Inc.            Topic: 172

    The goal of this project is to develop a microand nanofluidic DNA sizing platform with a sensitivityspeedand dynamic range that is unmatched by current sizing technologiesWe find that fluorescence burst analysis of individual DNA molecules transported through sub micrometer scale channels provides accurate and precise sizing of fragments betweenbp ands of MbpIn this singlemolecule sizing platformu ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. AMBIENT LIGHT ACTIVATABLE OPSIN BASED THERAPY FOR AGE-RELATED MACULAR DEGENERATION

    SBC: NANOSCOPE TECHNOLOGIES LLC            Topic: NEI

    Severe loss of vision occurs due to age-related macular degeneration (AMD) and approximately 15 million people in the US have some form of AMD, which is expected to double by 2050. Most of the current clinical treatments are primarily focused on slowing down the progression of the disease, as there is neither a cure that can stop the degeneration nor a therapy, other than retinal prostheses, that ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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