Award Data

DESCRIPTION (provided by applicant): The ultimate goal of this project is treatment of beta-thalassemia, a genetic blood disease, with antisense oligonucleotides. The project is based on the technology developed by the PI in which antisense oligonucleotides are used to restore correct functioning of a defective gene rather than, as commonly practiced, to inhibit the expression of an undesirable ge ...

DESCRIPTION (provided by applicant): Adolescent drug use continues to be a major public health problem. The need for late onset drug prevention and early cessation in high schools is great, yet few universal programs exist that target alcohol, tobacco, and other drug use among high school students. Crossroads is a universal drug prevention program based on a cooperative relationship between high s ...

Three-dimensional woven and braided fiber architectures provide important advantages to composites, including suppression of delamination, high damage tolerance, improved through-the-thickness properties, simplicity and cost-effectiveness of manufacturing complex composite structural components. However, in order to diversify applications and reach high volumes of utilization of these materials in ...

The goal of this proposal is to develop a new method to create Non-Rotationally Symmetric (NRS) surfaces that overcomes the limitations of the current techniques and is fast, accurate and inexpensive. Diamond turning (DT) has revolutionized the fabrication of lightweight optical surfaces for defense and science applications such as forward-looking infrared radar and infrared spectrometers. It ha ...

Power generation, power distribution and electric propulsion on ships and aerospace vehicles could be made smaller, lighter, more efficient, more versatile, and lower maintenance by operating these systems—partly or entirely—at cryogenic temperatures. Our goal is to demonstrate the advantages of cryogenic operation in regard to electronic components, specifically semiconductor devices (power d ...

DESCRIPTION (provided by applicant): Hyperpolarized gases, both xenon-129 and helium-3, have demonstrated their utility in structural and functional lung imaging and quantifying lung disease. In contrast to helium-3, however, xenon is cheap and abundant. Its lower diffusion constant offers scientific advantages over helium, offsetting the disadvantage of its lower gyromagnetic ratio. Availability ...

Hyperpolarized gases, both xenon-129 and helium-3, have demonstrated utility in structural and functional lung imaging and quantifying lung disease. In contrast to helium-3, however, xenon is cheap and abundant. Its lower diffusion constant offers scientific advantages over helium, offsetting the disadvantage of its lower gyromagnetic ratio. Availability of a polarizer producing six liters per hou ...

Ultra-high performance multi-function RF electronics are required by the United States Department of Defense to enable next generation radar and sensor networks in response to an increasingly diverse array of threats to our military and our homeland. An elegant potential solution is that of gallium nitride (GaN) RF electronics, which has shown great promise on currently available yet foreign subs ...

Bearing failure in satellite applications is related to lubricant starvation rather than fatigue, and health monitoring systems for these applications must be able to observe subtle changes related to lubrication state. Phase I included an experimental study to identify candidate monitoring approaches, and the data collected confirmed that cage motion characteristics and instability are highly sen ...