Award Data

Bacterial overgrowth is a condition found primarily in the elderly and is estimated to affect 33% of people over 65 years. It causes great discomfort and clinically important nutritional deficiencies if left untreated. The underlying cause is reduced gastric acid secretion associated with aging. Management of overgrowth is hampered because low cost and easy to use diagnostic tests do not exist. ...

Sequencing the human genome has uncovered numerous putative novel targets for which 3D structures are not available and which have no known inhibitors. We proposed a system to use computational methodologies to generate 3D molecular models of target proteins, and to use these models to design novel chemical inhibitors. Currently, the system is capable of accurately folding a target's amino acid se ...

CRYOGENIC HELIUM REFRIGERATORS AND LIQUIFIERS CONVENTIONALLYEMPLOY OIL LUBRICATED POSITIVE DISPLACEMENT COMPRESSORS AT THE WARM END AND FREQUENTLY USE PISTON TYPE EXPANSION ENGINES AT THE COLD END. THESE SYSTEMS REQUIRE EXTENSIVE AND VIGILANT MAINTENANCE TO CONTROL CONTAMINATION FROM LUBRICATING OIL AND ITS VOLATILE COMPONENTS MIGRATING TO THE COLD END. HENCE THE NEED FOR LOW MAINTENANCE COMPRESSO ...

A prototype cooperative multi-robot control architecture suitable for the eventual construction of large space structures has been developed. Inspired by the biological example of cooperative nest building by social insects, the architecture's robotic construction agents perform their construction duties stigmergically, i.e., without direct inter-agent communication and without a preprogrammed glo ...

The proposed innovative analysis tool is driven by the need to integrate both analytical and experimental techniques when performing an experiment of spacecraft launch. When available, this tool provides an acoustic engineer access to both the experimental data being measured and analytical predictions that are derived from empirical models and a database. Thus, the proposed tool takes advantage o ...

We propose a new active broadband electromagnetic (EM) sensor to detect and classify naval mines buried in the littoral. The sensor will work like an underwater metal detector, but it will operate at multiple programmable frequencies suitable to a given littoral environment. Once it detects a potential target, the sensor will interrogate the target and measure its spectral responses (inphase and q ...

Combustor Lean BlowOut (LBO) is a significant challenge in modern military gas turbine combustors. LBO can occur either during rapid engine deceleration or during operation at idle conditions with water/steam ingestion. Current practice is to design adequate safety margins to avoid the onset of blowout. However, significant engine performance improvements can be realized though the development o ...

RESEARCH AND DEVELOPMENT WILL BE CARRIED OUT TO PROVIDE PROTOTYPE, ACTIVELY CONTROLLED GAS BEARINGS FOR PRECISION MOVEMENT IN INSTRUMENTS AND MACHINE TOOLS. THIS WILL DRAW UPON PRELIMINARY WORK ON (1) FABRICATION, (2) DYNAMIC ANALYSIS OF THE BEARING AND SUPPORTED MASS, (3) PIEZOELECTRIC VALVING AND PIEZOELECTRIC DISPLACEMENT OF THE BEARING SURFACE, AND (4) THE ADAPTATION OF A MICROPROCESSOR TO SER ...

DESCRIPTION (provided by applicant): The objective of this proposal is to develop and validate a novel wrist brace that reduces the risk for wrist fracture by resisting wrist terminal extension while otherwise allowing unconstrained movement throughou

Location 1903 N HARRISON AVE, STE 101 CARY, NC 27513 United States N44MH0664102C $365 147.00 2 005 ADAPTING EXISTING CURRICULA FOR PROMOTING SOCIAL AND ADA Department of Health and Human Services National Institutes of Health SBIR PHS2006-1 THREE C INSTIT ...