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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Targeting leukocyte metabolism to treat human autoimmune disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has defined an anti-MCT1 monoclonal antibody (mAb) that will be developed for the treatment of human autoimmune disease. The membrane monocarboxylate nutrient transporter SLC16A1 (MCT1) is a multi-pass transmembrane protein responsible for the facilitated transport of critical metabolites, including products of glycolysis: lactate, pyruvate and ketones. Our strong preliminary data support ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. BioSphincter to Treat Fecal Incontinence. Phase 1/2 Clinical Trial. SBIR Phase IIB

    SBC: CELLF-BIO, LLC            Topic: 300

    Project Summary AbstractFecal incontinenceFIthe involuntary soiling of various amounts of liquid and solid stoolis often devastating from a socialpsychologicaland hygiene perspectiveMen and women suffer from FI equally with a range ofin people agedyearsThe prevalence increases to overin people older thanyearsFI may result from an isolated or combined loss of smooth muscle functionIASskeletal muscl ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. CometChip: Development of a high throughput DNA damage assay in hepatocytes

    SBC: Integrated Laboratory Systems, LLC            Topic: NIEHS

    An estimated 10,000 animals are used in toxicology safety assessments to meet all regulatory requirements with testing spanning 5 to 10 yrs and exceeding $10 million dollars. There is a critical need to reduce reliance on animal testing and to develop highly predictive human-based biological models for safety assessments. Replacement of traditional animal toxicity tests for toxicology safety asses ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Point-of-care device to identify patients at risk for preeclampsia

    SBC: AFFINERGY, LLC            Topic: N

    Although international trends for maternal mortality have shown an overall decline, maternal mortality rates in the United States have increased by andgt;25% since 2000. One of the leading causes for this increase is preeclampsia, a complication of pregnancy characterized by elevated blood pressure, proteinuria, and endothelial dysfunction involving multiple organ systems. Worldwide, preeclampsia ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. AM for Missile Defense

    SBC: AURA Technologies, LLC            Topic: MDA16013

    We propose to create a system that integrates simulation capabilities into design software that will allow MDA the ability to quickly vet new AM parts with 150x improvement in efficiency. This will allow more machine up time, less cost, and faster design iterations.

    SBIR Phase II 2018 Department of DefenseAir Force
  6. Swimmer Detection Sonar Network- Phase II: Integration Architecture

    SBC: Scientific Solutions, Inc.            Topic: N022071

    Under this SBIR project we are developing a Swimmer Detection Sonar Network (SDSN). The SDSN concept is to deploy a large number of networked inexpensive sonar nodes to protect a harbor or pier against terrorist swimmers. Under Phase I SBIR funding we developed potential schemes for the difficult task of integrating many sonar nodes. Under other funding provided by both the Republic of Singapor ...

    SBIR Phase II 2004 Department of DefenseNavy
  7. Device for rapid extraction of rare pathogens from raw samples

    SBC: Redbud Labs, Inc.            Topic: R

    ABSTRACTRedbud Labs proposes to develop a low costintegrated microfluidic system to purify and concentrate pathogens directly frommL of whole bloodwith the goal of improving the sensitivity of downstream blood culture and molecular diagnostic assays used in sepsis diagnosis and treatmentPhase I studies have demonstrated that our technologybased on actuated surface attached postsASAPscan achieve hi ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Accelerated discovery of methylation targeted therapeutic development

    SBC: Epicypher, Inc.            Topic: 102

    PROJECT SUMMARYNucleosomesNucsare the repeating units of chromatinmade up of DNA wrapped around a histone octamerChanges in chromatin structurefunction can dramatically impact downstream gene expression and cellular physiologydriving oncogenic reprogramming and cancer progressionThis epigenetic regulation of chromatin is controlled by two major modificationshistone post translational modifications ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. HLS- Cyclic CAR peptide: a targeted therapy for pulmonary hypertension

    SBC: VASCULAR BIOSCIENCES, INC.            Topic: NHLBI

    PUBLIC ABSTRACT This projectin response to announcement HLSdescribes a development program for CARSKNKDCCARa synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapiesfor the treatment of pulmonary hypertensionPHPH is a disorder of elevated pulmonary vascular resistance characterized by progressive thickeni ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a first-in-class therapeutic for producing 'on-demand' voiding

    SBC: Dignify Therapeutics LLC            Topic: 400

    PROJECT SUMMARYABSTRACTAging and diabetesas well as many neurological conditionssuch as multiple sclerosisParkinsonandapos s diseasespina bifidastrokeand spinal cord injurySCIcan result in loss of voluntary voiding of urine and require intermittent bladder catheterization for voidingCatheter use is associated with increased incidence of health problemspredominately repeated urinary tract infection ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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