Award Data

Reduced-mass polymer composite materials are crucial to the success of aerospace systems for reducing vehicle weight. But, composite material adoption is inhibited because the autoclave consolidation required is prohibitively expensive for the large tanks and skins contemplated in the Next Generation Launch Technology (NGLT) Program. To remedy this, NASA-LaRC has been developing cost-effective, ...

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Three-dimensional woven and braided fiber architectures provide important advantages to composites, including suppression of delamination, high damage tolerance, improved through-the-thickness properties, simplicity and cost-effectiveness of manufacturing complex composite structural components. However, in order to diversify applications and reach high volumes of utilization of these materials in ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

We propose to continue the development of rapid, handheld multiplexed assays for the detection of biological warfare agents and an associated handheld automatic reader. We will rigorously evaluate the 5-target assay developed in Phase I, and develop an 8-target multiplex during this Phase II project. The handheld automatic reader will undergo further modification and improvements to provide for ...

Insuring the safety and control of littoral waters is problematic because of the difficulties of surveillance. The preferred methods of surveillance in the ocean are acoustic. In littoral waters, acoustic methods fail because noise from the surf and reflections from the shallow bottom convolute acoustic signatures beyond our capacity to discern them. Water absorbs light, reducing the effectiven ...

DESCRIPTION (provided by applicant): The overall objective of the proposed work is to reduce the cost of accelerator produced F-18 radiopharmaceuticals used in Positron Emission Tomography (PET), a Medicare-reimbursed nuclear medicine metabolic imaging modality used to diagnose, stage, and restage ten cancer indications. Annual PET scans (350,000+) are rapidly increasing, but CMS reimbursement ...

DESCRIPTION (provided by applicant): The overall objective of the proposed work is to reduce the cost of accelerator produced F-18 radiopharmaceuticals used in Positron Emission Tomography (PET), a Medicare-reimbursed nuclear medicine metabolic imaging modality used to diagnose, stage, and restage ten cancer indications. Annual PET scans (350,000+) are rapidly increasing, but CMS reimbursement ...

DESCRIPTION (provided by applicant): Traumatic brain injury (TBI) is the leading cause of death and disability in the US with an incidence rate of 1.5 million at cost of $56.3 billion annually. There is no treatment for TBI, and the lack of therapeutic intervention for a public health issue of this magnitude constitutes a healthcare crisis. We have developed COG133, a peptide that is neuroprotecti ...

We propose to develop multiresolution representations and algorithms for synthetic terrain environments. They will be used for representing large terrain models as well dynamic and atmospheric simulations. Our ultimate goal is to increase the validity of the simulation by incorporating the multiple models at varying resolutions. We will use the OneSAF simulation Product Line Architecture Framework ...