Award Data

Project Summary Abstract Confusionbeing lostand losing track of oneandapos s orientation within large or unfamiliar indoor spacesthese are some of the biggest challenges facing people with visual disabilitiesSince GPS typically doesnandapos t work indoorsand isnandapos t fine grained enough anywayindividuals who cannot readily access visual information are at a significant disadvantageand many bli ...

An estimated 10,000 animals are used in toxicology safety assessments to meet all regulatory requirements with testing spanning 5 to 10 yrs and exceeding $10 million dollars. There is a critical need to reduce reliance on animal testing and to develop highly predictive human-based biological models for safety assessments. Replacement of traditional animal toxicity tests for toxicology safety asses ...

Diode-Pumped Alkali Lasers (DPALs) have great potential for high-energy lasers. Proper design of these systems is challenging because many interrelated processes impact their performance, and critical kinetic rate coefficients are not well known. In response, our team is developing a comprehensive physics-based analysis/design tool, and experimentally determining key kinetic rate coefficients. The ...

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it de ...

Solid rocket motor (SRM) design requires detailed understanding of the slag accumulation process in order to: predict thrust continuity, optimize propellant conversion efficiency, predict coning effects from sloshing, and to assess potential orbital debris (slag) hazard. Current state-of-the-art models for SRM environment do not have the capability to simulate the accumulation and dynamics of slag ...

Launch vehicles experience extreme acoustic loads dominated by rocket plume interactions with ground structures during liftoff, which can produce damaging vibro-acoustic loads on the vehicle and payloads if not properly understood and mitigated against. Existing capabilities for modeling turbulent plume physics are too dissipative to accurately resolve the acoustic propagation and detailed vehicle ...

Project Abstract Adolescents can benefit greatly from evidence basedmedically accurate sexual and relationship health educationHoweverboth teachers and parents face challenges in effectively teaching about sexual health and relationships leading to students receiving incomplete or inaccurate informationYoung people turn to the media for informationand many media messages about sex and relationship ...

Although international trends for maternal mortality have shown an overall decline, maternal mortality rates in the United States have increased by andgt;25% since 2000. One of the leading causes for this increase is preeclampsia, a complication of pregnancy characterized by elevated blood pressure, proteinuria, and endothelial dysfunction involving multiple organ systems. Worldwide, preeclampsia ...

Integrated Solutions for Systems, Inc. (IS4S) and teammate Auburn University (AU) propose to develop a PNT initialization system for dismounted soldiers. The proposed system will enhance warfighters’ ability to operate immediately in a GPS denied environments once their mission begins and has wide commercialization potential outside of DoD. In Phase I, the feasibility and expected benefits of in ...

PUBLIC ABSTRACT This projectin response to announcement HLSdescribes a development program for CARSKNKDCCARa synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapiesfor the treatment of pulmonary hypertensionPHPH is a disorder of elevated pulmonary vascular resistance characterized by progressive thickeni ...