Award Data

This project creates a Web-based Occupational Resource Kit (W.O.R.K.), the first self-paced, adaptive job skills intervention designed specifically to meet the learning styles and social-emotional needs of students with intellectual disabilities. W.O.R.K. enhances students’ preparedness for postsecondary employment, optimizing the likelihood of success in the workforce following completion of hi ...

The goal of this contract is to synthesize a heparan sulfate HS library consisting of structurally homogeneous oligosaccharides in response to an SBIR contract call from NCl Chemically Defined Glycan Libraries The Contractor specializes in the synthesis of structurally diverse HS oligosaccharides The Contractor has built an innovative chemoenzymatic method for Glycan synthesis Polymeri ...

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Modern drug discovery methods require the use of automated liquid handling and dispensing systems for screening large numbers of candidate compounds to identify new drug candidates The use of these high throughput methods has been made possible by the development of automated systems that can dispense extremely small volumes of reagent at high speed However many of the reagents used in testing ...

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DESCRIPTION provided by applicant The long term objective of this project study is to develop a monoclonal antibody that inhibits the progression of diabetic retinopathy Insulin like growth factor I IGF I has been implicated in both endothelial dysfunction as well as the proliferative phase of the disease but IGF I concentrations in retina are not increased During hyperglycemia IGF I activa ...

DESCRIPTION provided by applicant Malignant primary brain tumors represent the most frequent cause of cancer death in children and young adults and account for more deaths than cancer of the kidney or melanoma Glioblastoma GBM is uniformly lethal and current therapy is non specific and produces a median overall survival of andlt months In contrast immunotherapeutic approaches are exq ...

DESCRIPTION provided by applicant Capture Pharmaceuticals Inc is developing a drug called C E for treatment of individuals who have been contaminated by radioactive transuranic elements either by accident or following a nuclear terrorism event C E is a radionuclide decorporation agent that works by binding these elements in the bloodstream and enhancing their elimination before they can b ...

DESCRIPTION provided by applicant Chronic wounds that fail to respond to traditional therapeutic interventions afflict millions of people each year and direct costs associated with treating these wounds are estimated at $ billion annually in the U S alone Eradication of pathogenic bacteria that have colonized chronic wounds is complicated by the propensity of these bacteria to form biof ...