Award Data

The chloroperoxidase enzyme from the filamentous fungus Caldariomyces fumago has applications in industrial chemical synthesis and the detection and inactivation of chemical warfare agents. Chloroperoxidase is capable of regio- and enantioselective oxygenations and halogenations of organic substrates. When performed chemically, these reactions typically require aggressive reagents and reaction c ...

The ability to direct the wound pathways following injury could provide a critical path in wound care at crucial times during the progression of healing. A promising field of study in wound healing is epigenetics; alterations in gene expression caused by mechanisms other than changes in DNA sequence. Identification of epigenetic factors and their manipulation may result in the development of nov ...

The technical objectives of this Phase II project are to identify unique biomarkers and produce molecular, antibody and peptide reagents that are specific for human prostate cancer progenitor stem cells. We propose to utilize the information from the Phase I award and subsequent research to develop assay reagents that would be used to develop a blood-based assay specific for circulating prostate c ...

U.S. Military operations have come to depend more and more on unmanned vehicles (unmanned undersea vehicles UUVs and unmanned air vehicles UAVs) to carry out numerous missions. However, the transit distance for many of these missions is often well limited by the energy storage capacity of their power systems. Fuel cell, particularly SOFC that can be fed directly with reformate, looks promising. Co ...

Physically Unclonable Devices (PUFs) have many applications in security and digital rights management. These devices are used in creation of random number generators used to seed key generation and one-time pad construction for encryption applications. They are also used as a means of uniquely authenticating a piece of hardware or computing device. Given the large applicability of field programmab ...

Mg alloys such as AZ31 are attractive for military armor applications, because of their strength to weight ratio, and ease of machining. Research has shown that reduction of grain sizes below 100 nm can result in an increase in material performance, and strength. However Mg nano-particles can be dangerous to process, as a result of their pyrophoric nature, and very sensitive to corrosion and oxida ...

Amplification Technologies proposes to demonstrate the feasibility of developing novel low light level solid state imaging arrays utilizing the break through technology of discrete amplification technology with very high gain, low noise, high detection efficiency and having no external quenching circuits. It is expected that the proposed devices would have significantly superior performance charac ...

Techshot proposes to improve the isolation and immunoselection of mesenchymal stem cells from adipose tissue using Quadrupole Magnetic flow Sorting (QMS). This separator technology sorts magnetically labeled cells at high speed and is capable of processing large volumes of tissue such as lipoaspirate digests. QMS has previously been employed to isolate hematological cells from blood and Pancreatic ...

We propose to use a novel gauge along with our innovative optical fabrication methods to deterministically finish a concentric dome with an embedded conductive grid.

To address the need of the Army in a deterministic method for generating a dome with precise location of a buried grid, Applied Science Innovations proposes development of the Electro-Optical Depth Sensor (EODS), a new tool for non-contact depth measurement. The non-contact measurement from either inside or outside surface of the dome, accurate to better than1 mil, will be independent of the surfa ...