Award Data

DESCRIPTION (provided by applicant): This program will demonstrate the potential for commercial success of a novel approach for tracking and displaying the position and orientation of instruments in image-guided cancer interventions. Prototype systems will be demonstrated in selected pancreatic procedures in human subjects. New clinical applications will be examined and commercialization will beg ...

DESCRIPTION (provided by applicant): This project proposes to build and test a 20 L capacity Remediator for medical wastes. Infectious Medical Wastes (IMW), mainly from hospitals, represents a major component of hazardous wastes generated in the U.S.. In f act, more than 4.5 million tons are generated per year. Hospital waste remediation was a 1.5 billion industry in 2003. Incineration remains th ...

DESCRIPTION (provided by applicant): BioInVision, Inc. and Case Western Reserve University researchers will develop a cryo-imaging system for 3D imaging of mice. It will serve very many applications in biological research and the biotechnology industry, in cluding mouse anatomical phenotyping, drug delivery, imaging agents, metastastic cancer, pathogen/immune system response, and stem cells/regene ...

DESCRIPTION (provided by applicant): A coupling mechanism with the strength to fix a forcefully contracting muscle to a totally inert prosthesis, or to bone, would meet a serious and common need in clinical orthopaedics. We have explored a new approach t o such a coupling. The hypothesis was that a coupling prosthesis with a low-mass, high-surface configuration designed to transfer force by shea ...

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess a Wireless Movement Disorder Monitor (WMDM) specifically tailored to Parkinson's disease (PD). Major PD symptoms that affect quality of life include tremor, bra

DESCRIPTION (provided by applicant): We propose applying innovative measurement technology to develop and disseminate a comprehensive function and disability assessment instrument for use in gerontological research and practice. This technology offers an e ffective method to resolve the classic conflict between practicality and psychometric adequacy faced by traditional standardized outcome measur ...

DESCRIPTION (provided by applicant): Our objective is to achieve a major advance in the technology used to assess disability in children and youth. Measurement and practical requirements for identifying disability and evaluating individual progress across pediatric age groups and care settings present a serious dilemma to current fixed-item survey instruments. In Phase I proposals, we have develo ...

THE PROPOSED RESEARCH IS INTENDED TO SHOW THE FEASIBILITY OFDEVELOPING A COMMERICAL ULTRASOUND MAMMOGRAPHY SYSTEM (NONIONIZING MODALITY) WITH A DETECTION ABILITY SIMILAR TO X-RAY MAMMOGRAPHY SYSTEMS (LESIONS 5 MM OR LESS), AND BASED ON COMBINED TISSUE AND BLOOD-FLOW IMAGING. THE BLOOD-FLOW IMAGING IS SIGNIFICANT, SINCE MALIGNANT TUMORS EXHIBIT DRAMATICALLY INCREASED VASCULARITY AND BLOOD FLOW WHEN ...

The speed at which an attack is detected is a critical trigger for all responses to follow. The accurate determination of the type of attack will determine the type of emergency personnel and response needed. The location will determine the target response area as well as determine by proximity which of the responders that are available can be first on the scene. Therefore, a system that can do th ...

STUDIES IN THIS PROPOSAL WILL BE AIMED AT THE PREPARATION OFA SUPPOSITORY FORMULATION OF A PRO-DRUG OF DELTA-9-TETRA- HYDROCANNABINOL (^9-THC) AND STUDY THE BIOAVAILABILITY OF THC FROM THIS FORMULATION AS COMPARED TO I.V. ADMINISTRATIONOF BOTH THC AND ITS PRODRUG. BIOAVAILABILITY STUDIES WILL BE CONDUCTED IN MONKEYS, AND BLOOD SAMPLES WILL BE COLLECTEDAT 0, 15, 30, 60, 90, 120, 180, 240, AND 480 M ...