Award Data

DESCRIPTION (provided by applicant): Severe sepsis is a major cause of morbidity and mortality throughout the world. It is the leading cause of death in non-coronary intensive care units (ICUs) in the United States, with more than 750,000 cases occurring every year. This means that in the United States, more than 500 patients die from severe sepsis every day, with 28% to 50% of the patients succum ...

DESCRIPTION (provided by applicant): During Phase I of our proposed research, we will develop and validate procedures for recovering, labeling, and analyzing miRNAs from fixed tissue samples. The procedures will be based on the miRNA microarray and fix ed tissue RNA isolation systems that we developed in other SBIR-funded programs. The development of our miRNA isolation and labeling procedures ...

DESCRIPTION (provided by applicant): This program will demonstrate the potential for commercial success of a novel approach for tracking and displaying the position and orientation of instruments in image-guided cancer interventions. Prototype systems will be demonstrated in selected pancreatic procedures in human subjects. New clinical applications will be examined and commercialization will beg ...

DESCRIPTION (provided by applicant): This project proposes to build and test a 20 L capacity Remediator for medical wastes. Infectious Medical Wastes (IMW), mainly from hospitals, represents a major component of hazardous wastes generated in the U.S.. In f act, more than 4.5 million tons are generated per year. Hospital waste remediation was a 1.5 billion industry in 2003. Incineration remains th ...

DESCRIPTION (provided by applicant): This is a SBIR Phase II application for developing microfluidic microchips containing 30k protein kinase (PK) substrate peptides for proteomic PK profiling of cell lysates. In recent years there has been a dramatic expa nsion in our understanding of PK (kinome) biology.1-7 In addition to the fundamental role of PKs in protein post-translational modification and ...

DESCRIPTION (provided by applicant): BioInVision, Inc. and Case Western Reserve University researchers will develop a cryo-imaging system for 3D imaging of mice. It will serve very many applications in biological research and the biotechnology industry, in cluding mouse anatomical phenotyping, drug delivery, imaging agents, metastastic cancer, pathogen/immune system response, and stem cells/regene ...

THE PRIMARY OBJECTIVE OF THSES STUDIES IS TO DETERMINE THE FEASIBILITY OF USING THE CLONED LUX GENE SYSTEM ISOLATED ON A PLASMID EXPRESSION VECTOR FROM LUMINOUS MARINE BACTERIA AND EXPRESSED IN E. COLI (OR POSSIBLY OTHER BACTERIA) TO DETECT TOXIC SUBSTANCES IN WATER. NUMEROUS TOXIC SUBSTANCESATTENUATE THE LUMINESCENCE FROM MARINE BACTERIA. THIS IS PRESUMABLY DUE TO THE INSERTION OF THE TOXIC MATER ...

DESCRIPTION (provided by applicant): A coupling mechanism with the strength to fix a forcefully contracting muscle to a totally inert prosthesis, or to bone, would meet a serious and common need in clinical orthopaedics. We have explored a new approach t o such a coupling. The hypothesis was that a coupling prosthesis with a low-mass, high-surface configuration designed to transfer force by shea ...

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess a Wireless Movement Disorder Monitor (WMDM) specifically tailored to Parkinson's disease (PD). Major PD symptoms that affect quality of life include tremor, bra

DESCRIPTION (provided by applicant): We propose applying innovative measurement technology to develop and disseminate a comprehensive function and disability assessment instrument for use in gerontological research and practice. This technology offers an e ffective method to resolve the classic conflict between practicality and psychometric adequacy faced by traditional standardized outcome measur ...