Award Data

DESCRIPTION provided by applicant Hearing loss is a leading public health concern with about of American adults reporting some degree of impairment Of those fewer than seek help for their condition for a variety of reasons To address this issue the National Institue of Deafness and Other Communication Disorders NIDCD is seeking solutions to improve hearing healthcare access and l ...

PROJECT SUMMARY This program aims to develop a novel non opioid therapeutic for the treatment of pain that targets a subtype of the human voltage gated Na ion channel NaV Preliminary data indicate that SiteOneandapos s lead drug candidates may be more effective than opioids for treating certain types of pain and lack the side effects associated with opioid analgesics which include nausea ...

DESCRIPTION provided by applicant This is a resubmission of a Phase I Phase II Fast Track application for the clinical use of MultiStem in patients with acute respiratory distress syndrome ARDS ARDS is defined as acute onset hypoxemia bilateral radiographic pulmonary infiltrates and lack of atrial pressure hypertension A novel and exiting possibility is the use of cells as part of the ther ...

Smoking is the most common preventable cause of morbidity and mortality in the United States Each year smoking causes the premature death of over Americans and $ billion of economic damage Effective treatment is possible but barriers to its implementation limits the success rate of smoking cessation in the general population to about Notably reward based incentive smoking cessat ...

Abstract For the first time it is possible to directly visualize a radiation beam hitting a patientandapos s tissue or high resolution imaging of radiation delivery in water tank phantoms using Cherenkov emission imaging This allows the opportunity to do pre treatment verification at high resolution with real time video of a test phantom prior to delivery to the patient Radiotherapy has a di ...

Project Summary This direct Phase II SBIR proposal focuses on the development of recombinant human MGrhMGa novel tissue repair proteinas a therapeutic candidate targeting injury of renal epithelium to protect against acute kidney injuryAKIAKI is commonly encountered in the hospital and outpatient settings and is associated with a high rate of mortalityCurrentlythere is no effective means for preve ...

Despite significance advances in anti retroviral treatments HIV associated neurocognitive disorder HAND remains prevalent and can affect a broad range of everyday activities An effective brief cognitive screen that could be implemented in busy HIV clinics where clinicians have limited time to provide care for patients with complex medical psychiatric and cognitive conditions has the poten ...

Abstract The ultimate goal of the proposed project is to develop a commercial illumination device detection system kit and original ELISA diagnostic kits for detection of HIV p antigen in human serum or plasma by a photochemical amplification method PAM developed within Phases I and II The methods for identifying HIV infection include HIV antibody tests viral isolation through viral cultur ...

Abstract It has become evident that the microvasculaturei emicroscopically small blood vesselsplays a critical role in the plasticity of the brain for fundamental processesineurogenesisiimigration of neuronal precursors to their final destination in the brainiiiaxonaldendritic and synaptic plasticity during brain developmentlearningaging and neurodegenerationandivrecovery from traumatic brain inju ...

Abstract This project aims to develop a novel systemSpines InvestigatorTMfor performing automated four dimensionalDquantitative analysis of changes in dendritic spine morphology on three dimensionalDmicroscopic images acquired with in vivo multiphoton fluorescence microscopy at different time pointsThe role of dendritic spines is one of the most active and important areas of neuroscience researchP ...