Award Data

DESCRIPTION (provided by applicant): Between 10% and 20% of the United State population suffer from seasonal influenza each year. While most individuals recover from influenza in one to two weeks, the very young, the elderly and persons with chronic medical conditions can develop post-flu pneumonia and other lethal complications. The causative agent of influenza is influenza virus, a myxovirus tha ...

This program will use a combination of hardware and software to remove narrow band interference from Satellite Communications (SATCOM) equipment. The system that will be developed in the phase II will act as a black box, which sits between the original SATCOM antenna system and SATCOM receiver, and will utilize spatial and time diversity combined with statistical methods to remove the interference ...

DESCRIPTION (provided by applicant): With the considerable success of our phase 2 SBIR, we have achieved the completion of lung image analysis software that segments and thoroughly measures the lungs and their five lobes along with the airway tree. We have recently just achieved 510(k) FDA clearance for Pulmonary Workstation (PW 2.0) which now opens the door to the use of the Phase 2 software in t ...

DESCRIPTION (provided by applicant): The principal goal of this research project will be to evaluate 4-demethyl-4- cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN), a polychlorinated cholesterol carbonate as anticancer therapy for patients with advanced cancer in a Phase II clinical trial. During pre-clinical studies DM-CHOC-PEN produced complete remissions with long term survival vs. intracranial ...

DESCRIPTION (provided by applicant): Our understanding of complex biological phenomena and disease progression has led to the realization that changes in the expression of genes underlie many of these processes. Developing reagents that can selectively alter the expression level of any desired gene has been a goal of both scientists and clinicians for years. Historically, the most common approach ...

DESCRIPTION (provided by applicant): 7-Butyl-10-aminocamptothecin (BACPT), as a water-soluble dipeptide pro-drug - BACPTDP, is a novel camptothecin analog that has increased activity in hypoxic/acidic tumor tissues, characteristic of fast growing cancers that characteristically have deficient vasculature and outgrow their blood supply. Both in vitro and in vivo studies support the potential useful ...

The objective of this project is to develop a software based FOB energy simulation model that will enable the USMC to effectively analyze FOB energy efficiency under various configurations and assess the impacts of current and emerging conventional and alternative power systems. At the end of Phase II, MDD will have developed a comprehensive energy simulation and analysis tool, with the following ...

The objective of this project is to promote and realize improvements in readiness, sustainability and availability for US Air Force weapons systems and platforms. The centerpiece of Phase II is the primary set of process workflows which provide for the accomplishment of Supply Chain Management (SCM) mission objectives. This will be achieved through the use of normalization techniques; a common me ...

The SKATE concept was designed to quantify skill levels of trainees, teams, or units, generate skill-appropriate training scenarios, and provide a continuous skill-level assessment of disparately skilled trainees, teams, and units in a joint training exercise while maintaining the overall integrity and realism of the mission itself. SKATE evaluates the skill level of an individual, teams, or unit ...

The goal of this program is to develop compact, lightweight, low power thermal management systems for non-lethal weapons platforms, specifically the Radio Frequency Vehicle Stopper (RFVS) and the Active Denial Technology (ADT) system. In the Phase I effort, Mezzo designed thermal management systems for both applications which utilize Mezzo"s advanced micro tube heat exchangers and micro tube therm ...