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DESCRIPTION provided by applicant Genital tract infection with Neisseria gonorrhoeae gonorrhea does not induce a state of specific protective immunity and can be acquired repeatedly Despite public health measures the disease persists at an unacceptably high frequency and resistance even to the latest generations of antibiotics continues to emerge There is no vaccine available and none ap ...

DESCRIPTION provided by applicant Vector control remains the only means to combat many important mosquito borne pathogens including the viruses responsible for West Nile Dengue and Chikungunya A key deficiency of existing vector control methods is the inability to affect cryptic breeding sites which provide refugia to immature mosquitoes and allow for the rapid recovery of mosquito populations fol ...

DESCRIPTION provided by applicant The objective of this proposal is to demonstrate the feasibility of an innovative injection device proposed product to improve upon intratumoral delivery of liver therapeutics as compared to standard injection needles currently used Hepatocelluar carcinoma HCC will become an increasing burden on economic resources in the coming years as the prevalence of c ...

DESCRIPTION provided by applicant The Emergency Responder Health Monitoring and Surveillance ERHMS Technical Assistance Document TAD aimed at National Response Teams highlights the need for a technology platform for collecting data before during and after disasters to assess the effect training has on response related illness and injury for emergency responders This SBIR grant applicati ...

DESCRIPTION provided by applicant This proposal is submitted in response to the new NIDDK announcement PA calling for development of new diagnostic monitoring and therapeutics technologies for the complications of type diabetes T D An estimated of the million diabetic patients in this country will develop diabetic foot ulcers DFU at some point in their lives Curr ...

DESCRIPTION provided by applicant The baculovirus expression vector system BEVS has been successfully utilized to produce thousands of proteins for use as vaccines and therapeutics as well as for studies of protein structure and function One limitation of BEVS is the propensity of baculoviruses to accumulate transposon insertions into the fp k gene leading to the andquot few polyhedra FP ...

DESCRIPTION provided by applicant ParaTechs Corporation develops innovative technologies for biomedical research while seeking to improve animal welfare for laboratory animals One of ParaTechsandapos major goals is to further the guiding principles of ethical animal use by andapos reducing replacing and refiningandapos the use of animals in research according to the guidelines of Russell a ...

DESCRIPTION provided by applicant FasCure Therapeutics focuses on the development of adjuvant systems to generate prophylactic and therapeutic immune responses The major objective of this Phase STTR proposal is to reformulate a lead plague subunit vaccine with a novel adjuvant system to improve its protective efficacy Yersinia pestis is the causative agent of bubonic and pneumonic plague ...

DESCRIPTION provided by applicant Bipolar disorder BD is a complex chronic illness characterized by recurrent often dramatic mood changes Self management of BD is an important component of treatment but is likewise complex and can be fraught with difficulties including misunderstanding of the condition and a lack of self awareness Combined with the nationwide shortage of mental healthcare ...