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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Medications for Synthetic Cannabinoid Abuse

    SBC: PAFOSPharma, LLC            Topic: R41

    PROJECT SUMMARY ABSTRACT In response to PAthis Phase I STTR proposal will aim at developing pharmacotherapies that can act aslife savermedications to counteract the neurotoxic effects of synthetic cannabinoidsSCsTowards this goalwe will synthesize CB R antagonists with fast onsets of action that can be administered in an emergency roomERsituationThe rationale is based on the successful soft agonis ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Mitigation of Radiation Therapy Induced Neuroinflammation and Cognitive Dysfunction

    SBC: ImmunoChem Therapeutics, LLC            Topic: 102

    PROJECT SUMMARY Cognitive decline and deterioration of long term cognitive performance are major side effects of CNS cancer treatmentBrain metastases are the most common CNS malignancies and a common cause of morbidity and mortality in aboutof all cancer patients with systemic diseaseaffecting overpatients in the US annuallyAs most systemic chemotherapy agents do not cross the blood brain barriert ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Developing a Scalable Manufacturing Process for an Oral Bacteriophage Product that Prevents Cholera

    SBC: PhagePro, Inc.            Topic: NIAID

    PROJECT SUMMARY Cholera is an acute and severe disease caused by the bacterium Vibrio cholerae that is spread primarily through contaminated water sources due to a lack of adequate sanitation infrastructureThe World Health Organization estimates that there are at leastmillion cases globally per yearpercent of which are spread through household transmissionCurrent prevention methods require signifi ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Lead Optimization of Peripheral CB1 Neutral Antagonists for Renal Diseases

    SBC: MAKScientific LLC            Topic: 400

    RESEARCH andampRELATEDUnitPROJECT SUMMARY ABSTRACT In response to PAthe aim of this Phase I STTR proposal is to optimize and develop peripherally actingcannabinoidreceptorCB Rneutral antagonists displaying favorable therapeutic profiles for treating diabetic nephropathyDNDN is a chronic diabetic kidney disease and affectstypeand typediabetic patientsIt is characterized by persistent albuminuria an ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. PAR2 Pepducins as a Novel Treatment of Idiopathic Pulmonary Fibrosis

    SBC: OASIS PHARMACEUTICALS, LLC            Topic: NHLBI

    Idiopathic pulmonary fibrosisIPFthe most common of the interstitial lung diseasesoccurs in aboutpeoplewithnew cases diagnosed annually in the USThe typical clinical course is a progressive fibrotic disease characterized by scarring and `honeycombingandaposof the lungs causing an irreversible loss of the tissueandapos s ability to transport oxygenCo morbid pulmonary hypertension is commonly seen in ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. MISSION U: A MULTIMEDIA TRAINING TOOL FOR TREATING INDIVIDUALS WITH CO-OCCURRING MENTAL HEALTH AND SUBSTANCE USE DISORDERS

    SBC: Praxis            Topic: 350

    Co occurring mental health and substance use disordersCODare common in the United States and providers have been challenged to provide effective treatmentsAs a consequencetheir clients with COD may experience poor treatment engagementsymptom exacerbation and cycle in and out of emergency servicesThis is particularly true for underrepresented populations with a COD including individuals whom are ho ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Online Training For Addressing Perinatal Depression

    SBC: Praxis            Topic: 104

    Project Summary The primary goal of this proposal is to developimplementand evaluate an online module to improve obstetric providersknowledgeattitudesand practices regarding perinatal mood and anxiety disordersUpwards ofinwomen suffer from perinatal mood and anxiety disordersLeft untreatedthey have deleterious effects on maternal and birth outcomesinfant attachmentand children s behavior developme ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Novel Flexible Access Port for Extra-Cardiac Beating Heart Repair

    SBC: Nido Surgical, Inc            Topic: NHLBI

    ABSTRACT The overall goal of this Phase I STTR project is to develop an epicardial endoscopic instrumentCardioPort ECfor safe and precise dissection and stabilization of the heart surface to enable epicardial ablation of ventricular arrhythmiasEffective treatment of ventricular tachycardiaa lifethreatening arrhythmiain patients with ischemic heart disease often requires both endocardial and epicar ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Establishing a mechanistic foundation for drug discovery: The ABCA4 transporter in Stargardt Disease and other retinopathies

    SBC: Rectify Pharmaceuticals LLC            Topic: NEI

    ABCAis an ABC transporter found in retinal photoreceptor cellsMutations in ABCAhave been implicated in retinopathies such as autosomal recessive Stargardt macular degenerationcone rod dystrophyretinitis pigmentosa and age related macular degenerationABCAfunctions as an importerandflippasemoving N retinylidene phosphatidylethanolamineN retinylidene PEfrom the lumen to the cytoplasmic leaflet of dis ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A universal mechanobiology tool for drug discovery in lung diseases

    SBC: Mechanobiologix L.L.C.            Topic: NHLBI

    Abstract Despite significant effortsno cure exists for the major respiratory diseases such as asthmaemphysema and pulmonary fibrosis due to a lack of proper preclinical methodsDrug development is often carried out in cultured cellsWhile amenable to imaging and manipulationthis approach lacks the native tissue environment and neglects the effects of mechanical forces due to breathing which influenc ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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