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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Rapid, Near-Tranfusion Test for Bacteria in Platelets Units

    SBC: IMMUNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Bacterial contamination of platelets is considered the greatest infectious risk of blood product transfusion today at about in platelet units which is several orders of magnitude greater than that of HIV Bacterial contamination at high levels can lead to severe morbidity or mortality in transfusion recipients The American Association of Blood Banks is ...

    SBIR Phase II 2016 Department of Health and Human Services
  2. Antibody targeting of ADAM for treatment of triple negative breast cancer

    SBC: Adecto Pharmaceuticals, Inc.            Topic: NCI

    DESCRIPTION provided by applicant Triple negative breast cancers TNBCs account for of breast cancer deaths and lack targeted therapies Drs Sonenshein Mineva and Romagnoli and their co workers recently identified the non essential cell surface protein ADAM A Disintegrin and Metalloprotease as a pivotal promoter of breast tumor growth and metastasis and validated it as a target o ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a STAT2 knock-out hamster model for wild-type filovirus infections

    SBC: Auratus Bio LLC            Topic: 200

    DESCRIPTION provided by applicant Golden Syrian hamsters offer certain advantages over the use of other rodents in the study of a number of human diseases In the context of cancer research the histological and cytogenetic changes in the development of pancreatic cancers are similar in humans and hamsters but not in mice Hamsters are also the model species of choice for studying oncolytic ad ...

    STTR Phase I 2016 Department of Health and Human Services
  4. Lipidated Stable BAM8-22 Offers a Promising Therapeutic for Neuropathic Pain

    SBC: On Target Therapeutics, LLC            Topic: 106

    DESCRIPTION provided by applicant Neuropathic pain is a serious health problem that affects millions of people worldwide and occurs in as much as of the general population The management of neuropathic pain in patients is complex with an estimated of individuals refractory to existing analgesic therapies The aging population the diabetes epidemic and the significant cohorts of can ...

    STTR Phase I 2016 Department of Health and Human Services
  5. Non-Invasive, Highly Specific Detection of Oxytocin in Biological Fluids

    SBC: Giner, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant Non Invasive Highly Specific Detection of Oxytocin in Biological Fluids Oxytocin a neuropeptide hormone plays an important role in a variety of complex social behaviors including affiliation sexual behavior and aggression It is best known for its role to facilitate the birth process through induction of myometrial muscle contractions However recent studi ...

    STTR Phase I 2016 Department of Health and Human Services
  6. Developing Therapeutics That Target RAD To Treat Leukemia and Lymphoma

    SBC: Cyteir Therapeutics, Inc.            Topic: NCI

    DESCRIPTION provided by applicant Genomic instability is a hallmark of cancer and represents a targetable vulnerability yet is underdeveloped as a therapeutic area The central goal of this Phase program is to complete the early preclinical development of a new class of new cancer therapeutics that uniquely target RAD delivering effective cancer cell selective therapy in subsets of bioma ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Optimization of a mucosal RSV vaccine

    SBC: Biomedical Research Models, Inc.            Topic: NIAID

    Abstract Human respiratory syncytial virus RSV is a highly infectious member of the paramyxovirus family causing upper and lower respiratory tract infections RSV is the leading cause of pulmonary disease of the lower respiratory tract bronchiolitis pneumonia and respiratory failure in infants due to virus induced airway damage and complex inflammatory processes and responsible for an estima ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Engineered bacteriophage as a platform to deliver nucleic acid based therapeutics to bacteria to disperse biofilms in implant-associated infections such as prosthetic joint infections

    SBC: EnBiotix, Inc.            Topic: NIAID

    Abstract Bacteriophages are viruses that specifically and solely infect bacteria and are a natural platform delivery system of genetic information encoded by nucleic acids to bacteria Lytic bacteriophages do not integrate their DNA into the bacterial chromosome but replicate independently and ultimately kill their host bacteria In the early andapos s bacteriophages were used to fight inf ...

    SBIR Phase I 2016 Department of Health and Human Services
  9. Evaluating the impact of novel inhibitors of nuclear pore export in SLE

    SBC: KARYOPHARM THERAPEUTICS INC.            Topic: NIAID

    DESCRIPTION provided by applicant Systemic lupus erythematosus SLE is a complex autoimmune disease with a broad spectrum of clinical manifestations affecting several organs and associated with dysregulation of the immune system This disease affects millions of individuals with women and underserved minorities disproportionately burdened It is associated with significant morbidity and morta ...

    SBIR Phase I 2016 Department of Health and Human Services
  10. Rapid Phenotypic Antibiotic Susceptibility Testing

    SBC: BIOSENSE TECHNOLOGIES, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Infectious disease has now entered a post antibiotic era where multi drug resistance is increasingly common There is an immediate need for new diagnostics that can determine the susceptibility of pathogenic bacteria to antibiotics rapidly and accelerate the administration of targeted therapy for optimal patient outcomes BioSense Technologies proposes the deve ...

    SBIR Phase I 2016 Department of Health and Human Services

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