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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Genome Mining the Full Diversity of the Actinomycete Biosynthetic Universe for Neomorph Antibiotic Discovery

    SBC: WARP DRIVE BIO, LLC            Topic: NIAID

    ABSTRACT To combat multidrug resistant bacterial infections novel classes of antibiotics with new mechanisms of action are desperately required Genome mining for novel natural products is quickly replacing traditional approaches to antibiotic discovery Warp Drive Bio has sequenced over actinomycete strain genomes from diverse sources worldwide and our proprietary genomic database conta ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Selection of a device for intranasal administration of a mucosal vaccine for HSV

    SBC: Biomedical Research Models, Inc.            Topic: R

    Globally an estimated of the human population is infected with HSV including andgt of the U S adult population Genital herpes is associated with an increased risk of HIV acquisition and transmission of HSV infection can cause neonatal herpes with high infant mortality HSV infection in the adult population has increased substantially in the past two decades despite the availabil ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Harnessing Genomic Information to Engineer Combinatorial Biosynthesis of a Large Polyketide Natural Products Library

    SBC: WARP DRIVE BIO, LLC            Topic: NIAID

    Abstract Natural products have outstanding pharmaceutical pedigree approximately of FDA approved small molecule drugs are derived from plant bacterial or fungal sources To discover new natural products Warp Drive Bio has assembled an enormous proprietary and searchable database of microbial genomes and biosynthetic gene clusters To date our database comprises genomes sequenced ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Platelet Bioreactor for Treatment of Radiation-Induced Thrombocytopenia

    SBC: PLATELET BIOGENESIS, INC.            Topic: R

    Platelet Biogenesis is developing a microfluidic bioreactor that reproduces key features of adult bone marrowphysiological microenvironmentto produce human plateletsPLTsPLTs are thebandaidsof the bloodstreamresponsible for clot formation and blood vessel repairLow PLT count is a significant consequence of a radiation accident or deliberate nuclear attackfor which PLTs are a critical first line the ...

    SBIR Phase I 2017 Department of Health and Human Services
  5. Screening for rAAV transduction enhancers

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    ABSTRACT Recombinant adeno associated virusrAAVis a promising gene delivery vector for therapeutic and vaccine applicationsbut its low transduction efficacy currently limits its utilityThe primary reasons for low transduction efficacy are as followsiinefficient trafficking of the rAAV genome to the nucleusiiinefficient host cell mediated synthesis of double stranded DNA from the single stranded ge ...

    SBIR Phase I 2017 Department of Health and Human Services
  6. Optical Dosimeter guided Photodynamic Therapy

    SBC: Physical Sciences Inc.            Topic: 102

    Photodynamic Therapy PDT is a promising modality for cancer treatment Oxygen molecules in the metastable singlet delta state O are believed to be the species that destroys cancerous cells during PDT Despite the benefit of targeted PDT that kills tumors selectively with minimum effect on surrounding healthy tissues at the present time it is difficult if not impossible to predict the res ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Improving delivery of paclitaxel to ovarian cancer via expansile nanoparticles

    SBC: IONIC PHARMACEUTICALS            Topic: 102

    ABSTRACT A primary challenge in ovarian cancer is preventing tumor recurrence in patients following a resection debulking procedure year survival rate andlt Intraperitoneal IP administration of chemotherapy most notably paclitaxel can improve patient outcomes and prevent local tumor recurrence the principal deterrent to long term survival However despite these modest improvement ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Immuno-PCR for Detection of Toxins in Medicinal Cannabis

    SBC: COURTAGEN LIFE SCIENCES, INC.            Topic: NIDA

    Abstract The overall goal of this project is to develop an optimized assay design and development process to permit the rapid implementation of sensitive bead based immuno PCR assays for the detection of the major bacterial and fungal toxins that are produced by common contaminants of medicinal cannabis The assay process will be developed and validated in Phase I focusing on one important small ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Novel Specific and Sensitive Mass Spectrometry Based Protein Ligand Binding Assay to Discover Novel Beta Lactam Antibiotics

    SBC: WARP DRIVE BIO, LLC            Topic: NIAID

    ABSTRACT There is a critical need to discover and develop safe and effective antibiotics for the treatment of multidrug resistant bacterial infections Each year approximately million patients in the US get hospital acquired infections HAIs with a mortality rate of Nearly of the bacteria causing HAIs are resistant to at least one commonly used antibiotic Natural products NPs a ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Long-acting ghrelin for the treatment of ARS

    SBC: Extend Biosciences Inc.            Topic: R

    Project Summary The threat of a radiation attack or accident isunfortunatelyall too real and could potentially affect a large enough population so as to overwhelm the medical systemTo be prepared for such an eventit is necessary to stockpile effective radiation medical countermeasuresMCMthat are safeeasily administered to large numbers of peopleand effective even when treatment is delayedhrs after ...

    SBIR Phase I 2017 Department of Health and Human Services

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