Award Data

ABSTRACTThe global death toll from Malaria is estimated to be upwards ofpeople each yearwith more thanchildren succumbing every dayPlasmodium falciparumPfSporozoiteSPZbased vaccines are the only intervention in humansproven to induce robusthigh levelandgtand long lastingat leastmonthsprotective efficacy against malariaforming the basis of Sanaria s unique technology platform of asepticpurifiedcryo ...

Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

This project develops new methods for fabricating replicas of museum artifacts and other 3D objects that describe themselves when touched, so that museums can create exhibits that are accessible to everyone, including visitors with visual impairments. Phase I demonstrated how ordinary capacitive touchscreens could be repurposed as sensors for determining locations of finger touches on 3D surfaces ...

This project develops an ultrasonic fitment tool to improve prosthetics performance for persons with lower-extremity amputations. The goal of this project is to develop a new clinical instrument used in the socket fitting process to optimize the performance of a lower-body prosthetic system and thereby improve mobility, activity, exercise, and quality of life for over 2 million American amputees. ...

This proposal addresses the significant public health threat posed by the spread of Taenia soliumthe pork tapewormin at risk human populationsInfection with Tsoliumor Taeniasiscan lead to Cysticercosiscaused by the migration and encystment of larval Tsolium in the central nervous systemCysticercosis is a severe to fatal disease which affects overmillion people worldwideprincipally in less develope ...

Fungal endophthalmitis is an infection inside the eye after corneal transplant surgery caused by contamination of the transplanted tissueAccording to the Eye Bank of Americathe incidence of postsurgery endophthalmitis more than doubled fromtoand thatof the culture positive cases were due to Candida yeastEnvironmental contamination as well as current corneal preservation conditions contribute to th ...

The development of a healthy behaviors through active design tool supports the initiatives focused on nutritionphysical activityand obesity by utilizing an evidence based web application to offer design solutions that influences healthy choicesThis feasibility study provides a prototype and establishes the commercial merit of the resulting research based applicationproviding health and wellness fe ...

The problems this contract is addressing include making it easy for patients to report toxicities after radiation therapy so that they can be timely and accurate and so that they can be incorporated into a medical database for use by medical professionals. This would allow the app to recommend (when appropriate), and for clinicians to intervene, with appropriate treatments and will lead to better ...

Cancer patients receiving radiation therapy experience toxic side effects of the radiation, and sensitivity to radiation is variable across both patients and tumors, and is poorly understood. This Phase I SBIR project aims to design and demonstrate the feasibility of a Patient Reported Outcome mobile application for surveillance of RADiotherapy toxicity (PRORAD) that integrates NIH's Patient Repor ...

Here we propose to study two injectable formulations that provide different delivery routes for Talazoparib, potent PAPR inhibitor: An implant, InCeT-Talazoparib, which can be injected directly in the tumor where it will act as a sustained release depot of Talazoparib over a prolonged period of approximately 30 days. It delivers 100% of the drug to the tumor site with almost no systemic toxicity. ...