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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. A Bioactive Polymer Designed for Cardiac Assist Devices

    SBC: ABIOMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the development of a novel, bioactive polymer for use in ventricular assist devices (VAD), and other long-term blood contacting implantable devices. Although VADs are becoming an important therapeutic option for patients in heart failure, serious problems persist secondary to thromboembolic complications and continue t ...

    SBIR Phase I 2003 Department of Health and Human Services
  2. An Artificial Myocardium for Pediatric Support

    SBC: ABIOMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the commercialization of a pediatric ventricular assist device (VAD). Although, VADs, both implantable and paracorporeal, have become an important surgical option for adult patients with myocardial failure unresponsive to less aggressive therapy, no VADs are commercially available for short-term use in children or smal ...

    SBIR Phase I 2003 Department of Health and Human Services
  3. New Agents That Inhibit Fatty Acid Accumulation

    SBC: ADIPOGENIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. Although weight loss is the most effective treatment for type 2 diabetes, current methods for reducing weight typically are insufficient for long-term weight loss. The mission of AdipoGenix, Inc. is to discover, develop and license novel the ...

    SBIR Phase I 2003 Department of Health and Human Services
  4. Activators of Adipocyte Fatty Acid Oxidation

    SBC: ADIPOGENIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Obesity is a well-established risk factor for a number of diseases, including type 2 diabetes and coronary heart disease. Existing drug and dietary treatments for obesity are only modestly effective. An approach that is very likely to be effective in treating obesity and with a good side effect profile is a drug that acts directly on lipid metabolism in the fat ...

    SBIR Phase I 2003 Department of Health and Human Services
  5. Combination of GM-CSF with TKR gene therapy

    SBC: ADVANTAGENE, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Combined gene therapy (Herpes Simplex Virus Thymidine Kinase + Anti-herpetic Prodrug) and radiation therapy (TKR therapy) is a novel approach in the armamentarium against cancer. This radio-gene therapy combination creates a new spatial co-operation whereby two local treatment modalities have demonstrated enhanced local and metastatic tumor control and prolong ...

    SBIR Phase I 2003 Department of Health and Human Services
  6. Biothreat Detection with Improved Background Rejection

    SBC: Aerodyne Research, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The Quartz Crystal Microbalance (QCM) is a well-established technology for quantifying small changes in mass. The long-term objective of this program is to improve the QCM so that it is suitable for use as a field test for the common, foodborne bacteria. To do this, we will modify the standard quartz crystal (QC) used in the QCM so as to increase its background ...

    SBIR Phase I 2003 Department of Health and Human Services
  7. Multiplex polony genotyping

    SBC: AGENCOURT BIOSCIENCE CORPORATION            Topic: N/A

    (Revised Abstract) Description: The ascertainment of millions of SNPs in the human genome, characterization of haplotype blocks and development of improved SNP-based linkage panels has fueled the need for accurate, efficient, and low cost SNP genotyping technologies to support genetic inheritance and disease association studies. The overall goals of this proposal are to develop and test a novel m ...

    SBIR Phase I 2003 Department of Health and Human Services
  8. Cellular Microarrays for in vitro toxicology screens

    SBC: AKCELI, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The studies outlined in this proposal are the first steps towards the establishment of a high throughput in vitro toxicology screen using mammalian cells. Toxicological screens are a critical component of the drug discovery process but are often employed late in the process due to the constraints of cost and throughput. The enablement of valid toxicology scr ...

    SBIR Phase I 2003 Department of Health and Human Services
  9. NearlR Photon-counting Camera for Optical Tomography

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Early detection and routine clinical screening represent the first line of defense for preventing fatalities from cancer, a disease, which claimed 551,833, lives in the U.S. during the year 2000. Significant advances have been made in the medical imaging of tumors; however, many of these techniques are too expensive to be implemented for routine screening. D ...

    SBIR Phase I 2003 Department of Health and Human Services
  10. A Portable Biosensor for Francisella tularensis

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Radiation Monitoring Devices, Inc. proposes to design and build a portable bacteria sensor to identify Francisella tularensis, a CDC Category A agent of bioterrorism, in the field. The instrument will consist of a disposable microfluidic platform for carrying out the fluorescence labeling and immunocapture steps and a fluorescence detector utilizing our single- ...

    SBIR Phase I 2003 Department of Health and Human Services

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