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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Intravascular Cardiac Assist System for Decompression and Recovery

    SBC: ABIOMED, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this proposal is to develop a less invasive long-term copulsation device to treat patients in late Class III and early Class IV stages of heart failure (HF). Chronic congestive heart failure is the largest unsolved problem in cardiac care today. There are over 5.5 million people in the United States with this diagnosis and the number of patient ...

    SBIR Phase II 2010 Department of Health and Human Services
  2. A Novel Polymeric Percutaneous Heart Valve Prosthesis

    SBC: ABIOMED, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this SBIR program is the modification of a polymeric trileaflet heart valve to a valve prosthesis that can be delivered percutaneously as a transcatheter aortic valve replacement. Key innovations include improved durability and hemodynamic properties, lower manufacturing costs, and simplified delivery over existing transcatheter bioprosthetic v ...

    SBIR Phase I 2010 Department of Health and Human Services
  3. Minimally Invasive Pediatric VAD for Treatment of Acute Heart Failure

    SBC: ABIOMED, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The overall objective of this proposed program is the commercialization of the Pediatric Impella system, a minimally invasive ventricular assist device (VAD) for treatment of acute heart failure in pediatric patients. The device will be a less traumatic alternative to extracorporeal membrane oxygenation (ECMO), the current standard of care for these patients. T ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. Compact Chemical Sensor for Measurement of Internal Dose of Environmental Agents

    SBC: AGILTRON, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Detection of exposure to environmental agents by measurement of internal dose of such agents or their metabolites, chemical or biological, requires rapid assessment and identification of exposure to both known and unknown threats. Fast detection and identification of exposure to such threats can provide prompt warning of the extent and severity of the exposure ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. High Performance Detectors for SPECT

    SBC: Radiation Monitoring Devices, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Abstract Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or a research animal. Typically, the collected data are d ...

    SBIR Phase II 2010 Department of Health and Human Services
  6. Photonic Bandgap Structures for Improved Timing and Spatial Resolution in PET Det

    SBC: Radiation Monitoring Devices, Inc.            Topic: NIBIB

    DESCRIPTION (provided by applicant): Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. Imaging modalities such as positron emission tomography (PET), single photon emission computed tomography (SPECT), digital radiography (including digital mammography) and X-ray CT are critically important for cancer diagnosis, stagi ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. New Design of a Sensor for Ultrahigh Performance SPECT Imaging

    SBC: Radiation Monitoring Devices, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Among the various functional imaging techniques, SPECT maintains an important and growing role in the study of disease models in small animals as well as in patient care. Many SPECT-labeled imaging probes that have highly specific distributions with very little background are being used to measure a wide range of biological parameters of importance in small ani ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Simultaneous PET-MR Small Animal Imaging

    SBC: Radiation Monitoring Devices, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Simultaneous PET-MR Small Animal Imaging Principal Investigator: Dr. Gerald Entine, Ph.D. Abstract: The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. DEVELOPMENT A PROPRIETARY TIP-ENHANCED RAMAN SPECTROSCOPY

    SBC: Radiation Monitoring Devices, Inc.            Topic: NCI

    Mutation of genetic DNA is a major factor causing cancer. Locating these changes in the DNA sequence of single molecules is difficult because they cannot be assayed by conventional sequencing techniques. This project will demonstrate sequencing capabilities for single stranded DNA and RNA immobilized on a novel substrate, and demonstrate a novel method for increasing throughput. Sensitivity to mid ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Improved Continuous Autologus Blood Reinfusion Device Using an Ultrasonic System

    SBC: Radiation Monitoring Devices, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Surgeons face several challenges associated with intra- and post-operative blood loss. A limited supply of blood available for transfusion and injurious results involving transfusion reactions and disease transmission using allogenic blood, make blood component separation, embolus removal, and reinfusion of the patient's own shed blood an attractive option. In ...

    SBIR Phase I 2010 Department of Health and Human Services

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