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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Multi-Organizational Knowledge Based Approach Research

    SBC: 10 BLADE, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase 1 STTR project will determine the feasibility of using web services, based on standard SOAP/XML (HL-7) protocols, to exchange Emergency Medical Services (EMS) field data with disparate hospital information systems. It will build upon a pre-hospital software package called iRevive, which consists of a network of wireless, handheld computers linked ...

    STTR Phase I 2004 Department of Health and Human Services
  2. Nano-Ceramic for Metabolic Stem Cell Engineering

    SBC: Angstrom Medica, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this project is to develop a clinically and commercially viable tissue engineered bone construct using nanocrystalline ceramic scaffolds for proliferating and differentiating adipose-derived progenitor cells into cells of the osteogenic lineage. The use of a nanostructured hydroxyapatite (nano-HAP) scaffold offers several advantages for ...

    STTR Phase I 2004 Department of Health and Human Services
  3. Engineering Myoblasts for Transplantation

    SBC: Biomedical Research Models, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The primary goals of stem cell biology are to develop practical cell-based tools: 1) to enhance the repair of damaged organs and tissues; and 2) as vehicles for gene therapy to introduce engineered genes to the body to either correct a genetic defect or to provide therapeutic molecules. The use of embryonic stem cells is both controversial and fraught wit ...

    STTR Phase I 2004 Department of Health and Human Services
  4. New Model For Virus Induced Autoimmunity

    SBC: Biomedical Research Models, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this program is to validate a new animal model for virus-initiated autoimmunity using our colony of congenic Lew.IWR1 rats. Preliminary data demonstrate that this laboratory strain is susceptible to induction of autoimmune diabetes by a variety of methods including intraperitoneal injection of rat parvovirus (KRV), antibody depletion of regulat ...

    STTR Phase I 2004 Department of Health and Human Services
  5. Development of Infection-Resistant Suture Materials

    SBC: BIOSURFACES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Infection remains as one of the major complications associated with utilizing biomaterials. Surgical site infections account for approximately 14-16% of the 2.4-million nosocomial infections in the United States, with these infections resulting in increased patient morbidity and mortality. The inherent bulk properties of various biomaterials, including those ...

    STTR Phase I 2004 Department of Health and Human Services
  6. Development of a Ras-Targeted Cancer Therapeutic

    SBC: Gene Regulation Laboratories            Topic: N/A

    DESCRIPTION (provided by applicant): The concept of targeting cancer therapeutics towards specific mutations or abnormalities in tumor cells not found in normal tissues has the potential advantages of high selectivity for the tumor and correspondingly low secondary toxicities. At least 20% of all human malignancies display activating mutations in the p21 Ras genes, and perhaps another 60% display ...

    STTR Phase I 2004 Department of Health and Human Services
  7. Pharmacophore-Modeled Screening for HbF-Inducing Agents

    SBC: Gene Regulation Laboratories            Topic: N/A

    DESCRIPTION (provided by applicant): Induction of endogenous fetal globin (HbF) can ameliorate the clinical severity of the beta globin disorders. Many short chain fatty acids and derivatives (SCFADs) stimulate activity from the fetal globin gene promoter, and some create an accessible chromatin structure through HDAC inhibition and histone hyperacetylation. However, the available SCFA drugs requi ...

    STTR Phase I 2004 Department of Health and Human Services
  8. Nuclear Transfer Embryos from Tetraploid Embryos

    SBC: GTC BIOTHERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this proposal is to produce tetraploid embryos for aggregation with nuclear transfer embryos for the production of transgenic cattle and goats. GTC Biotherapeutics (formerly Genzyme Transgenics Corporation) has developed the expression of recombinant proteins in the milk of transgenic dairy animals. The milk of transgenic goats and cattle is a ...

    STTR Phase I 2004 Department of Health and Human Services
  9. Hyperspectral Imaging to Predict and Assess Foot Ulcers

    SBC: Hypermed, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): New therapies addressing complications of foot disease would significantly impact the lives of people with Type 1 diabetes. A quantitative method to evaluate the efficacy of a therapeutic regimen, or better, to define issue at risk and prevent initial ulcer formation would be highly beneficial. Our long-term objectives are to reduce the frequency of diabetic ...

    STTR Phase I 2004 Department of Health and Human Services
  10. Computerized ASI Follow-up and Outcome System

    SBC: Inflexxion, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Substance abuse service delivery systems are expected to conduct outcome studies but lack the resources and expertise needed to collect follow-up data. In this STTR, Inflexxion and Brandeis University's Heller School for Social Policy and Management propose to develop the Computerized ASI Follow-up and Outcome System (CAFOS). CAFOS will empower administrator ...

    STTR Phase I 2004 Department of Health and Human Services

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