Award Data

HCV infects about 3% of the world's population and most people are unaware of the infection status. About 80% of individuals with HCV infection develop chronic hepatitis and many progress to have cirrhosis and hepatocellular carcinoma (HCC). An early diagnosis in the course of the disease not only increases the chances successful treatment, but also effectively limits further transmission of HCV ...

Liver Cancer is the sixth most common cancer and the third leading cause of cancer death worldwide. Early diagnosis of liver cancer will have a significant impact on survival by implementation of effective tratment strategies. The development of novel biomarkers in serum for liver cancer proteomics will significantly improve noninvasive for early detection of liver cancer. This proposal is to ...

The project goal is to research and identify a confidential and technologically feasible method to communicate HIV/STD and preventive EOB information to young woman ages 19 to 25 through a moble application. Engineered Care will speak with privacy and HIPPA experts, payors, technology experts managing payor claims data and youth advocates to prototype a feasible smartphone mobile application. EC i ...

To assess the readiness of EHR systems to support this new capability by constructing prototype eMeasure software, interfaced to at least one EHR system, that implements the chlamydia screening rate eMeasure based on HEDIS specifications for the numerator and denominator. Success in Plase I will support a Phase II activity to extend the prototype to additional EHR systems and additional existing a ...

Diphtheria is an acute bacterial disease with a considerable case fatality rate caused by toxigenic Corynebacteria. Diphtheria toxin (DT) is the major virulence factor for these organisms. DT is synthesized and secreted as a single-polypeptide pro-enzyme that is cleaved and reduced in vivo to produce a toxic protein consisting of A and B fragments (1). DT has an estimated lethal dose for humans of ...

Monoclonal anitbodies (Mab) have been used successfully for treating human diseases. However, conventional Mabs are derived from mouse. Injection of murine Mabs into humans will cause adverse effects. The development of human Mabs against diphtheria could offer a commercially viable alternative to equine antitoxin for treating human diphtheria with a number of potential advantages including hig ...

? DESCRIPTION (provided by applicant): Alcoholic liver disease is a highly prevalent and costly condition affecting millions of people globally. Alcohol results in high morbidity and mortality an is responsible for nearly 4% of all deaths worldwide. Despite the tremendous societal and economic burden, there is no approved therapeutics for alcoholic liver disease. Instead, the standard of care ...

Abstract Persistent injury to the liver can cause chronic inflammation and dysregulated deposition of extracellular matrix (ECM), leading to accumulation of fibrotic scar tissue and eventually cirrhosis. While fibrosis is a normal wound healing response, in excess, it can further injure tissue and activate pro-fibrotic cells, resulting in a positive feedback loop. Scar tissue is not static, ECM re ...

DESCRIPTION (provided by applicant): The measurement of testosterone levels is central to the diagnosis of androgen disorders in men and women. Circulating testosterone is bound largely to sex hormone binding globulin (SHBG) and albumin; only the unbound or free fraction is biologically active. Therefore, in conditions that affect SHBG concentrations, such as aging, obesity, and diabetes, the dete ...

DESCRIPTION (provided by applicant): The ultimate goal of research into the biology of aging is to identify pharmaceutical interventions to increase both lifespan and healthspan of humans. The natural product rapamycin has been shown to significantly extend the lifespans of all model organisms tested including fungi, flies, worms, and mice. However, chronic treatment with rapamycin also causes unw ...