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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Photostable Fluorescent Probe For Imaging Live Cells Alternative To Quantum Dot

    SBC: ABD BIOQUEST, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Since the earliest examination of cellular structures, biologists have been fascinated by observing cells using light microscopy. The advent of fluorescent labeling technologies plus the plethora of sophisticated light microscope techniques now available make studying dynamic processes in living cells almost commonplace. The ability to visualize, track, and qu ...

    SBIR Phase I 2008 Department of Health and Human Services
  2. A universal TET system for implanted life support systems

    SBC: ABIOMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The ultimate objective of this proposed program is the commercialization of a universal transcutaneous energy transfer (TET) system with a high performance implantable battery. This integrated power system will be adapt able to a host of next generation fully implantable mechanical circulatory support (MCS) systems. To date, fully implantable systems (i.e. the ...

    SBIR Phase II 2008 Department of Health and Human Services
  3. Nutrition Initiative for Small Chain Restaurants (NISCR)

    SBC: ACCENTS ON HEALTH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Nutrition Initiative for Small Chain Restaurants (NISCR) Project Summary/Abstract To help combat obesity and diet-related diseases prevalent in the U.S., the proposed project will develop a program that enables and enco urages small chain restaurants to (1) serve a selection of healthier menu items and provide corresponding nutrition information and (2) promo ...

    SBIR Phase I 2008 Department of Health and Human Services
  4. Novel Catheter for Treatment of Ventricular Tachycardia

    SBC: Thermedical Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Ischemic ventricular tachycardia (VT) is a contributing cause to more than half of the 300,000 sudden cardiac deaths that occur annually in the United States. Implantable cardioverter defibrillators (ICDs) are the stand ard therapy but they are expensive the total cost of an ICD implant approaches 50,000 and the United States spends more than 2.2B on these im ...

    SBIR Phase II 2008 Department of Health and Human Services
  5. Scalable tools for the analysis of chemical compounds using graph-based querying

    SBC: Acelot, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Our current capacity to generate chemical and structural biological data far exceeds our capability to meaningfully assimilate it. The data describes molecules and biological macromolecules and associated properties. A principle common to the structure of all chemical and biological macromolecular entities is the composition of objects related by energetic int ...

    SBIR Phase II 2008 Department of Health and Human Services
  6. Electron Spin Resonance Microanalyzer

    SBC: Active Spectrum, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Electron spin resonance spectrometry is a widely used technique for the detection of free radicals and paramagnetic centers. There are over 23,000 published biomedical research papers citing this technique, particularly the use of spin labeling and measurement of reactive oxygen species and reactive nitrogen species. However, applications of electron spin reso ...

    SBIR Phase I 2008 Department of Health and Human Services
  7. Multiplex Gene Expression in Single Cells for Circulating Tumor Cell Detection

    SBC: ADVANCED CELL DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The detection and enumeration of circulating tumor cells (CTCs) has the potential to become a very powerful tool in cancer diagnosis and treatment. However, current technologies for CTC detection are not yet established in routine clinical practice. One reason is that CTCs are present in blood at an extremely low concentration of one in 10 million white blood ...

    SBIR Phase II 2008 Department of Health and Human Services
  8. Defining Therapeutic Potential of Clonal Stem Cell Populations using Targeted Nan

    SBC: OCATA THERAPEUTICS, INC.            Topic: N/A

    Project Summary Embryonic stem cells offer considerable potential for cell replacement therapy where cells have been lost to injury or disease because of their capacity for continual self renewal and ability to differentiate into virtually any cell type or tissue. Currently, however the process by which human embryonic stem cells (hESCs) differentiate into various mature functional cell types is ...

    SBIR Phase I 2008 Department of Health and Human Services
  9. iGenomeTM Software Platform Prototype for Individual Genetic Health Assessment

    SBC: 3RD MILLENNIUM, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Sufficient general clinical knowledge, DNA sequence technology and understanding of genetic mutations for over 2,600 human genes can support beginning the integration of individual genome sequence into clinical practic e for a number of medical specialties. With the 2007 deployment of novel DNA sequence technologies that permit cost-effective interrogation of ...

    SBIR Phase I 2008 Department of Health and Human Services
  10. A small molecule screen to target viral RNA-protein complexes

    SBC: ADVANCED GENETIC SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): There is a significant need for novel HIV therapies given the emergence of viruses resistant to existing drug regimens. RNA-protein complexes represent an important and under utilized drug target. In HIV, the Tat-TAR an d Rev-RRE RNA- protein complexes carry out essential roles in RNA transcription and nuclear export respectively. Disruption of these RNA-protei ...

    SBIR Phase I 2008 Department of Health and Human Services

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