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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Therapeutic Antibodies for Rabies

    SBC: Trellis Bioscience, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Trellis Bioscience has developed its patented CellSpot technology into a robust platform for characterizing the secreted antibody from single human lymphocytes with regard to specificity and affinity against multiple antigens. For example, the platform was used to isolate a rare, high quality human antibody to Respiratory Syncytial Virus (RSV) that is now bein ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Therapeutic Antibodies for Bacteria

    SBC: Trellis Bioscience, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Trellis Bioscience has developed its patented CellSpot technology into a robust platform for characterizing the secreted antibody from single human lymphocytes with regard to specificity and affinity against multiple antigens. For example, the platform was used to isolate a rare, high quality human antibody to Respiratory Syncytial Virus (RSV) that is now bein ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs

    SBC: NetBio, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Improved diagnosis of Neisseria gonorrhoeae (GC) infections represents a critical unmet medical need. The CDC estimates that approximately 700,000 people are infected by GC annually, with approximately half of these cases reported. The clinical spectrum of GC infection includes urethritis and cervicitis, pelvic inflammatory disease (PID), and disseminated disea ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Identification of novel influenza antivirals

    SBC: Arisan Therapeutics, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): The influenza A virus represents one of the greatest global human health risks. Although vaccines provide significant protection from seasonal flu infections they still account for an estimated 36,000 deaths and 200,000hospitalizations per year in the US alone. Furthermore, the inherent time involved in development, production and distribution of vaccines limit ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. A Combination Therapy Approach to Treating Drug Resistant Fungal Infections

    SBC: Amplyx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): There is an urgent need to discover more effective therapeutic regimens for fungal infections. Nosocomial infections caused by Candida albicans have a 50% mortality rate. Aspergillosis is a leading cause of death in organ transplant recipients, as well as patients suffering from cancer and auto-immune disorders. The annual cost of treating fungal infections is ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Origami MALE CONDOM-3: Feasibility and Acceptability Study, Phase 1 Clinical Resear

    SBC: Strata Various Product Design            Topic: NIAID

    DESCRIPTION (provided by applicant): The primary objective of this project is to build on prior Phase 1 research to improve product sensitivity properties, to refine and test modifications of the Origami Male Condom 1 (OMC 1), and develop a more consumer-acceptable device exclusively for vaginal-penile intercourse, the Origami Male Condom 3 (OMC 3). Made of custom formulated biocompatible, viral-i ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. SAMBA HIV-1 Semi-quantitative Test for resource limited settings

    SBC: DIAGNOSTICS FOR THE REAL WORLD LIMITED            Topic: NIAID

    DESCRIPTION (provided by applicant): The ultimate aim of this project is to develop a CE-marked and/or FDA-approved diagnostic platform for viral load monitoring of HIV-1 infected patients in point-of-care (POC) and resource- limited settings. Currently available viral load tests are not suitable for such settings due to their inherent high cost, complexity and size, thus patients, especially in t ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Development of Tissue Scaffold of High Strength and Porosity

    SBC: BIO2 TECHNOLOGIES, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): According to the Center of Disease Control and Prevention, arthritis is the greatest single cause of chronic pain and disability among Americans .2,3 Currently there is no cure for osteoarthritis, only medication and surgical procedures are available to alleviate the pain and discomfort associated with this degenerative bone disease. Current surgical treatment ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. An intramedullary device for less invasive surgical fixation of wrist fractures

    SBC: ENDOORTHOPAEDICS, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): The distal radius is one of the most common sites of bone fracture and is the most common fracture site in the upper extremity, accounting for approximately 10% of all fractures in adults. Approximately 25% of patients(~80,000/year) require surgery to correctly repair this bone, and current practice requires the surgeon to disrupt the soft tissues surrounding t ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Amelioration of Claustrophobia and Disruptive Patient Motion in MR Imaging

    SBC: HYPNALGESICS, LLC            Topic: NCCAM

    DESCRIPTION (provided by applicant): Claustrophobia and disruptive patient motion are common impediments to MRI examination, but they may be prevented or ameliorated with a non-pharmacologic behavioral intervention administered by trained staff. The potential benefits of such an intervention are highly significant, considering that the alternatives are to cancel the study or administer sedation. I ...

    SBIR Phase I 2011 Department of Health and Human Services

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