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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Preclinical Development of Selective PKC_epsilon Inhibitors to Treat Alcoholism

    SBC: VM DISCOVERY, INC.            Topic: NIAAA

    DESCRIPTION (provided by applicant): Alcohol abuse and alcoholism (alcohol use disorders) are significant public health issues and represent one of the largest public health problems. In the United States alone, alcohol use disorders affect about 14 million people, costing approximately 184 billion a year due to lost wages, legal and medical costs from associated injuries and liver, cardiac, neop ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Responsible Retailing Program for Alcohol Retailers

    SBC: RRF FIELD SERVICES, LLC            Topic: NIAAA

    DESCRIPTION (provided by applicant): The Responsible Retailing Forum ( RRF ) has developed a new model to reduce sales of alcohol products to minors. Derived from recommendations contained in the Report on Best Practices for Responsible Retailing, prepared as a federal guidance document for the Center for Substance Abuse Prevention in 2002, the model employs a quality improvement approach to ass ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Life Is A Stage: Dementia Care and the Dramatic Arts

    SBC: HEARTHSTONE ALZHEIMER CARE, LTD            Topic: NIA

    DESCRIPTION (provided by applicant): Market potential exists for development of works of drama that can be performed in facilities providing care for persons with dementia, and which can involve such residents interactively. Therefore, the purpose of thisPhase 2 project is to refine two plays created in our Phase 1 SBIR (Life Is A Stage : Dementia Care and the Dramatic Arts) that can be performed ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. The Hearthside Book Club: Pioneering Dementia-Level-Appropriate Reading Materials

    SBC: HEARTHSTONE ALZHEIMER CARE, LTD            Topic: NIA

    DESCRIPTION (provided by applicant): An estimated 5.4 million Americans are currently suffering from Alzheimer's disease (AD), and AD cases are expected to rise at an alarming rate, so market potential exists for products, approaches, and/or training thatcan help treat and/or circumvent the challenging behaviors associated with the condition. One approach that has been shown to be effective i ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Expanding Healthcare Research Capacities through the Integration of Medicaid and

    SBC: Acumen, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): This STTR application requests funding to expand the capabilities of Acumen LLC's Medicare/Medicaid Research Information Center (MedRIC). To advance the quality of the data available for public policy research, MedRIC facilitates the acquisition of data from the Centers for Medicare and Medicaid Services (CMS) to participants of surveys and registries spon ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Protective biomarkers for the development of vaccines against malaria

    SBC: ImmPORT Therapeutics Inc dba Antigen Discovery Inc            Topic: NIAID

    DESCRIPTION (provided by applicant): For the Phase I SBIR grant we constructed a Plasmodium falciparum (Pf) 3D7 protein microarray containing 2,320 individual polypeptides representing 1,200 known and hypothetical proteins, or ~23 % of the entire Pf proteome. We showed that the individual proteins printed on those arrays captured antibodies present in sera from infected individuals and the amount ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. An Orally Delivered Booster Vaccine Candidate for Hepatitis B

    SBC: Applied Biotechnology Institute, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): There are 350 million people chronically infected with hepatitis B virus who have a high risk for cirrhosis of the liver and liver cancer resulting in approximately a million deaths annually. This is an alarming rate asthere has been a safe and efficacious vaccine on the market for more than twenty years. High costs of production, distribution and administratio ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Identification of Novel Broad Spectrum Influenza Virus Inhibitors

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Our goal is to develop small molecule inhibitors that target influenza entry. In Phase I, we identified several compounds that selectively inhibit the hemagglutinin (HA) mediated virus entry process. Three HA specific entry inhibitors (MBX494, MBX994, and MBX726) were selected for further research and development based on their antiviral potency, selectivity an ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. A fully integrated assay and platform for detecting Clostridium difficile.

    SBC: Claremont BioSolutions            Topic: NIAID

    DESCRIPTION (provided by applicant): The primary goal of this proposed project is to develop a point-of-care diagnostic assay and platform for the detection of Clostridium difficile from human stool. Two additional goals are to detect the hypervirulent strain of C. difficile B1/NAP/027 and to detect C. difficile spores from swabs of medical devices. C. difficile associated disease (CDAD) is now th ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 Agents

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The human herpesviridae family contains eight members divided into three subfamilies, designated alpha, beta and gamma. The alpha herpes viruses include herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and varicella zoster virus (VZV). The beta herpes viruses include human cytomegalovirus (HCMV), two variants of human herpes virus 6 (HHV ...

    SBIR Phase II 2012 Department of Health and Human Services

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