List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Novel Polymeric Trileaflet Heart Valve Prosthesis

    SBC: ABIOMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this proposal is to produce a fully characterized polyurethane heart valve prosthesis that will be ready for clinical evaluation. Existing replacement valves suffer from several shortcomings. Specifically, biological tissue fixation and methods used to mount the tissue to the supporting stent of bioprostheses cause time dependent structural changes ...

    SBIR Phase II 2007 Department of Health and Human Services
  2. BIOACTIVE POLYMER FOR VENTRICULAR ASSIST DEVICES- SBIR TOPIC #37

    SBC: ABIOMED, INC.            Topic: N/A

    N/A

    SBIR Phase I 2007 Department of Health and Human Services
  3. Improved system for producing adenoviral vectors

    SBC: ADVANTAGENE, INC            Topic: N/A

    First generation non-replicative adenoviral vectors show promise as anti-cancer agents and as prophylactic vaccines. Current methods for manufacturing these vectors use either the 293 cell line or the PER.C6 cell line. These producer cells provide complementary E1a and E1b viral function in the cell for disabled adenoviral vectors. The 293 cell line has been very useful and widely used for mak ...

    SBIR Phase I 2007 Department of Health and Human Services
  4. Clinical and Immunologic Evaluation of ProstAtak for Prostate Cancer

    SBC: ADVANTAGENE, INC            Topic: N/A

    DESCRIPTION (provided by applicant): The main objective of this project is to develop a new therapeutic to improve the outcome for patients with intermediate-risk prostate cancer. The indication is a first-line adjuvant to be combined with radiation therap y for prostate cancer. The desired outcomes are improved local control rate, decreased recurrence and improved disease-free survival. This gran ...

    SBIR Phase I 2007 Department of Health and Human Services
  5. Clinical study of AdV-tk radiogenetherapy for malignant*

    SBC: ADVANTAGENE, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Malignant gliomas have a very poor prognosis with median survival measured in months rather than years. It is a disease with great need of novel therapeutic approaches. Within cancer gene therapy the use of adenoviral vectors to deliver HSV-tk (AdV-tk) has been one of the most widely studied and promising approaches. A few dose escalation Phase I studies ha ...

    SBIR Phase II 2007 Department of Health and Human Services
  6. Breath Analysis using Quantum Cascade Lasers

    SBC: Aerodyne Research, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The analysis of components in human breath is a powerful non-invasive technique for the diagnosis and monitoring of asthma, cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The presence of elevated levels of nitric oxide (NO), carbon monoxide (CO), carbonyl sulfide (OCS), and ethane (C2H6) in the breath have been identified as biomarkers o ...

    SBIR Phase II 2007 Department of Health and Human Services
  7. OpenClinica: Open Source Platform for Clinical Research

    SBC: AKAZA RESEARCH            Topic: N/A

    DESCRIPTION (provided by applicant): We believe a key barrier to transforming clinical research is the lack of open, integrated, transparent technology solutions that address bottlenecks in information integration and business process management. Our viewpoint is supported by a recent Forrester Research study that identifies proprietary software as "one of the biggest barriers" to interoperability ...

    SBIR Phase II 2007 Department of Health and Human Services
  8. High Sensitivity Multi-Well Plate Reader Based on an Array of Photon Counting Det

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Title: High throughput and high sensitivity multi-well plate reader Project Summary/Abstract: The multi-well or microwell plate has become ubiquitous in research and clinical laboratories for processing multiple samples with high speed and reproducibility. These plates have a standard size (86 x 128 mm) and are available in 24, 96, 384, or 1536 well configurati ...

    SBIR Phase I 2007 Department of Health and Human Services
  9. Rapid Detection and Monitoring of Biomarkers for Traumatic Brain Injury

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Over 370,000 people in the US are hospitalized for traumatic brain injury (TBI) each year. In the US, the cost associated with the treatment, hospitalization and rehabilitation of TBI are estimated to be $48.3 billion annually. A fast, easy, accurate and effective test for brain injury is required to identify head trauma and monitor the progression of the condi ...

    SBIR Phase I 2007 Department of Health and Human Services
  10. Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Recent extraordinary developments in synchrotron radiation sources have enabled the growth of powerful research techniques such as time-resolved X-ray diffraction studies for understanding dynamic biological phenomena and recovering phase information in X-ray crystallography. To make the most effective use of these advanced synchrotron sources for important pro ...

    SBIR Phase I 2007 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government