Award Data

Cancer survivors commonly report cognitive impairments following chemotherapy. With a growing number of cancer survivors comes an increased urgency to better understand the precise etiology and prevalence of cognitive changes associated with cancer and cancer treatment. This pursuit is impeded by a lack of assessment tools that can accurately detect the full scope of cognitive deficits. To address ...

DESCRIPTION (provided by applicant): Pancreatic adenocarcinoma has a dismal 5-year survival of andlt;5%. The only potential curative treatment is resection, but this is achieved in andlt;20% of patients and most still die due to micrometastases or residual disease. Patients with unresectable disease receive palliative chemotherapy with a median survival of less than 11 months. This application pro ...

SF424 – Project Summary Understanding how the brain generates certain behaviors requires an understanding of the function of individual neurons in dynamical neural circuits. Currently, there are few technologies available however that allow researchers to record both the activity within a brain region, and between brain regions in the brains of awake, behaving animals. Recent advances in microel ...

While biological models of mental illness once emphasized “chemical imbalances,” modern perspectives increasingly incorporate a more nuanced understanding of genetics and epigenetics, neurotransmitters and neuroplasticity, and the functional dynamics of neural circuits. Yet despite extraordinary advances in neuroscience that have dramatically enhanced our understanding of the brain and of the ...

PROJECT SUMMARY/ABSTRACT Opioid Use Disorder (OUD) is a key driver of the current opioid epidemic in the United States. Nearly 80% of individuals with OUD do not receive treatment. Buprenorphine Medication Assisted Treatment (MAT) is an effective form of care for OUD. Buprenorphine ameliorates craving and withdrawal, and reduces illicit opioid use, mortality, and problems associated with drug use. ...

Preceding Award: NCI Award 1R44CA192875-02 Project Summary: According to the Oral Cancer Foundation, about 50,000 people in the US will be newly diagnosed with oral cancer (OC) in 2017, causing 9,700 deaths[1]. OC is a severely neglected orphan disease with a lack of significant treatment advances in 4 decades[1]. Historically, OC has been present in heavy smokers and drinkers. However, more recen ...

The proposed Phase II SBIR project will develop a unique motor unit (MU) based control system (MU Drive™) that uses neural firings measured noninvasively and in real-time to drive an upper-limb prosthesis. Our Phase I effort successfully proved the technical merit and feasibility by demonstrating that MU firings can be measured from surface myoelectric recordings in real-time and used to provide ...

Project Summary Abstract This Phase II project aims to develop an automated system for extracting mesenchymal stem cellsMSCsalso known as multipotent stromal cellsfrom adipose tissues for treating many serious diseasesincluding myocardial infarctiongraft versus host diseaseand a variety of autoimmune diseasesOverclinical trials to date have established the feasibilitysafetyand in some cases effica ...

Project SummaryAortic stenosis (AS) is a common and lethal cardiac valve disease with an average survival time of only 2 – 3 years after diagnosis if no treatment is obtained. The standard of care for moderate to severe cases of symptomatic AS is surgical valve repair or replacement, which can necessitate open heart surgery. This “gold standard” of care is plagued by substantial limitations, ...

Both typeand typediabetes involve loss of insulin producing pancreaticcells resulting in inadequate insulin secretion to control blood glucoseand ultimately requiring daily insulin injections to avoid the constellation of life threatening complications that arise from long term hyperglycemiaWhile transplantation of cadaveric pancreatic islets that containcells has been successful for treating a sm ...