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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Babesia antigen detection assay for blood screening

    SBC: IMMUNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Human babesiosis is a malaria like illness caused by infection of red blood cells by the protozoan parasite Babesia microti or related species primarily transmitted to humans through the bite of infected deer ticks Babesiosis can also be transmitted by blood transfusion and is currently acknowledged as the foremost unaddressed infectious risk to the US blood ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Antithrombotic Diadenosine Tetraphosphate Analogs

    SBC: GLSynthesis Inc.            Topic: 100

    DESCRIPTION Undesired platelet activation can be result of many common pathologies or interventions Arterial thrombosis and the acute ischemic events that follow such as myocardial infarction and stroke are among the leading causes of death incapacitation and rising health care costs in the developed world Therefore antiplatelet drugs have significant market share and clinical importance ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Development of BA for treatment of cerebral cavernous malformation

    SBC: BIOAXONE BIOSCIENCES, INC.            Topic: 105

    DESCRIPTION provided by applicant Cerebral cavernous malformations CCMs also known as andapos cavernous angiomaandapos or andapos cavernomaandapos are common vascular abnormalities found in of the population exposing patients to a lifetime risk of hemorrhagic stroke seizures and other neurologic sequelae Approximately of CCM lesions present with clinically overt hemorr ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. IGF OT IGF SBIR TOPIC DIRECT TO PHASE II CLOSURE DEVICES FOR TRANSCAVAL ACCESS TO THE ABDOMINAL AORTA

    SBC: TRANSMURAL SYSTEMS LLC            Topic: NHLBI

    Not Available

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Antibiotics for Recalcitrant Infection

    SBC: Arietis Corporation            Topic: R

    DESCRIPTION provided by applicant The goal of the project is to develop a therapeutic capable of sterilizing recalcitrant chronic infections such as deep seated abscess osteomyelitis endocarditis and biofilms of indwelling devices Many of these infections are essentially untreatable and lead to substantial morbidity and mortality In many cases recalcitrance of an infection is not caused b ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. SBIR TOPIC 096:Novel Biodegradable Stents for Neonatal Aortic Coarctation

    SBC: 480 Biomedical Inc.            Topic: NHLBI

    Aortic coarctation is a common congenital heart condition that is usually recognized during the neonatal period early after birth The usual treatment is open surgery Non surgical catheter based stent therapy is not available to treat neonatal aortic coarctation because children outgrow commercially available metallic stents Absorbable stents might revolutionize the treatment of aortic coarctation ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Molecular Detection of Invasive Fungal Infections

    SBC: IMMUNETICS, INC.            Topic: R

    DESCRIPTION provided by applicant The incidence of invasive fungal infections and in particular Candida infections the fourth most common nosocomial pathogen has continued to increase over the past years This increase is due to the increasing numbers of patients subjected to severe immunosuppression as a result of transplant procedures chemotherapy regimens advances in medical and sur ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. The purpose of this contract is to develop an assay to detect minor populations of resistant variants in blood specimens from HIV-infected individuals with HIV RNA viral loads above 1000 copies/ml

    SBC: ALDATU BIOSCIENCES, INC.            Topic: NIAID

    Antiretroviral therapyARTreduces mortality and morbidity in HIV infected individualsbut specific HIV mutationsDRMsare associated with resistanceIt is now known that certain DRMs can contribute to virological failure even at very low concentrationsbut standard tests are inadequately sensitive to detect these minor variantsMethods to detect minor variants that contribute to HIV virological failure a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Noninvasive Neural Stimulation Technology

    SBC: HIGHLAND INSTRUMENTS            Topic: 102

    DESCRIPTION provided by applicant The past decade has seen a rapid increase in the application of brain stimulation devices to treat a variety of movement disorders such as Parkinsonandapos s disease PD and other neuropathologies Present noninvasive brain stimulation technologies suffer from fundamental limitations and have yet to reach the level of efficacy of invasive methods such as de ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  10. Optimization of novel pyranopyridine efflux pump inhibitors

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Multi drug resistance MDR in Gram negative pathogens including the Enterobacteriaceae and Pseudomonas aeruginosa poses a significant threat to our ability to effectively treat infections caused by these organisms A major component in the development of the MDR phenotype in Gram negative bacteria is overexpression of RND type efflux pumps which actively pu ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health

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