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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 24949 results
  1. Enabling Technology to Prepare Ultrapure Dialysate in Dialysis Clinics

    SBC: NOVAFLUX TECHNOLOGIES, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): The clinical significance of chronic pro-inflammatory reactions in dialysis patients due to exposure to endotoxin has become a central issue in nephrology. The European Renal Association urges the routine use of ultrapure dialysate with bacteria and endotoxin levels of lt 0.1 CFU/ml and lt 0.03 EU/ml, respectively. In the US, the maximum allowable limit of ba ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Inosine pro-drug: novel therapy for arthritis

    SBC: Inotek Pharmaceuticals Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is mediated by articular expression of pro-inflammatory cytokines and chemokines. We have discovered that the purine degradation product inosine exerts multiple anti-inflammatory and immunomodulatory effects via combined A2a and A3 agonism, resulting in suppressed expression of TNF-alpha, IL-1 beta, IL-12, MIP-lalpha, and IFN-gamma an ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. MyoRegulator: A non-invasive neuromodulation device for treatment of spasticity in stroke patients

    SBC: PATHMAKER MOBILITY CORP.            Topic: 101

    PROJECT SUMMARYABSTRACT Stroke affects overmillion patients in the U Swith an estimatedadditional cases of stroke occurring each yearOverof stroke survivors have spasticitya disorder of muscle tone that can cause striking impairments in functional movementPharmacologicalsurgical and physical treatments to manage spasticity haveat bestshort term efficacy and are confounded by side effectsIn this NI ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Development of an ALDH2-Targeting RNAi Therapeutic for Alcohol Use Disorders

    SBC: Dicerna Pharmaceuticals, Inc.            Topic: 150

    Abstract Alcohol Use DisorderAUDis a chronic condition characterized by compulsive alcohol useloss of control over alcohol useand a negative emotional state when not using alcoholwith such use associated with a range of medicalpsychologicalsocialeconomicand personal problemsAUD is global and prevalentin a survey of overadults in the USAUD had amonth prevalence ofaffecting overmillion adults in the ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. SYSTEMIC RADIONUCLIDE THERAPY TARGETED TO VEGF RECEPTORS IN TUMOR VASCULATURE

    SBC: SIBTECH, INC.            Topic: NCI

    The overall goal of this collaborative project between SibTech Inc PI Backer J and Johns Hopkins University PI Pomper M is clinical development of efficient and cost effective anti angiogenic Lu radiopharmaceutical scV Lu for VEGF receptor mediated targeting of angiogenic tumor vasculature Current very expensive anti angiogenic compounds induce transient regression of tumor vascula ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. IGF OT IGF I CLR AS A NEO ADJUVANT TREATMENT OPTION FOR TRIPLE NEGATIVE BREAST CANCER PERIOD OF PERFORMANCE

    SBC: Cellectar Biosciences, Inc.            Topic: NCI

    Poor prognosis of triple negative breast cancer TNBC is attributable to the absence of efficacious molecularly targeted neoadjuvant therapies Micrometastases contribute to poor prognosis by increasing recurrence rate Consequently an effective treatment option that is capable of targeting and sterilizing micrometastatic disease in patients with TNBC is warranted I CLR is proposed as ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Nitrogen Dioxide and Light-Absorbing Carbon Sensors for Personal Exposure Assessm

    SBC: AERODYNE RESEARCH INC            Topic: N/A

    DESCRIPTION (provided by applicant): This project addresses the need for the development of field deployable, sensors which provide real- time quantitative measurements at point-of-contact of airborne species that are injurious to human health - in this particular case, nitrogen dioxide and light-absorbing carbon. Nitrogen dioxide (NO2) is a highly toxic gas which when inhaled, causes the formati ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  8. Noninvasive brain stimulation for pain suppression

    SBC: HIGHLAND INSTRUMENTS INC            Topic: 213

    DESCRIPTION provided by applicant This proposal includes trade secrets and other proprietary or confidential information of Highland Instruments and is being provided for use by the National Institutes of Health NIH for the sole purpose of evaluating this SBIR proposal No other rights are conferred This proposal and the trade secrets and other proprietary or confidential information contain ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Therapeutics for Biodefense

    SBC: PARATEK PHARMACEUTICALS            Topic: N/A

    DESCRIPTION (provided by applicant): The relative ease of producing and distributing an agent of biological warfare makes future bioterrorist attacks an increasingly possible event. Since most of the bacterial agents used for such purposes are suscept

    SBIR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  10. High-Resolution, Spinal Cord Stimulation for Non-Opioid Treatment of Neuropathic Pain

    SBC: MICRO-LEADS INC            Topic: NINDS

    In this SBIR FastTrack proposalMicro Leads will develop HDa high resolutionchannel spinal cord stimulation therapy to provide more pain relief with greater specificity for those suffering from chronic neuropathic pain and opioid dependenceOvermillion in the U Ssuffer from debilitating pain in the trunk and extremities anddepend on opioids to ease their sufferingOpioid abuse has claimed the lives o ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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