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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 378: Symptomatic Toxicity Mobile Monitor (SympTMM)

    SBC: Vivonics, Inc.            Topic: NCI

    The goal of this NIH Phase I SBIR proposal is to develop and validate a new method to monitor the symptomatic toxicities and health-related quality of life of cancer patients who are undergoing and have undergone radiation therapy during the course of their treatment. The proposal is built around expertise in mobile application development (Vivonics Inc.) and radiation oncology (Dr. TJ Fitzgerald ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 378: PRORAD- A Mobile Application for Patient Related Outcomes of Radiotherapy

    SBC: Charles River Analytics, Inc.            Topic: NCI

    Cancer patients receiving radiation therapy experience toxic side effects of the radiation, and sensitivity to radiation is variable across both patients and tumors, and is poorly understood. This Phase I SBIR project aims to design and demonstrate the feasibility of a Patient Reported Outcome mobile application for surveillance of RADiotherapy toxicity (PRORAD) that integrates NIH's Patient Repor ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 374: Sustained Delivery of PARP Inhibitors for Cancer Chemoprevention

    SBC: TheraNano LLC            Topic: NCI

    Here we propose to study two injectable formulations that provide different delivery routes for Talazoparib, potent PAPR inhibitor: An implant, InCeT-Talazoparib, which can be injected directly in the tumor where it will act as a sustained release depot of Talazoparib over a prolonged period of approximately 30 days. It delivers 100% of the drug to the tumor site with almost no systemic toxicity. ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

    SBC: Zymeron Corporation            Topic: NCI

    Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. System for the Spec. of Acute THC Imp. Using Val. Alg.

    SBC: Charles River Analytics, Inc.            Topic: NIDA

    NIH through NIDA solicits the research and development of digital markers for detection of marijuana intoxication and cognitive impairmentIn this Project the ContractorCharles River Analyticsin partnership with the SubcontractorMcLean Hospitalproposes to design and demonstrate a prototype system for the Specification of Acute THC Impairment using Validated AlgorithmsSATIVASATIVAingests data across ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Measure of Dysfunctional Retinal Ganglion Cell Response

    SBC: Valenti, Denise            Topic: NIDA

    NIH through NIDA solicits the research and development of digital markers for detection of marijuana intoxication and cognitive impairmentIn this project the Contractor will develop and clinically validate a technology that indirectly tests retinal ganglion cell functionThe sensory psychomotor signal in the smartphone application named IMMAD is a visual field test using a small square with stripes ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Reagents for Immunologic Analysis of Non-mammalian Models

    SBC: Protein Innovation Labs, Inc.            Topic: NIAID

    The zebrafish is as an extraordinary model organism that provides unique opportunities for probing vertebrate biologywith direct implications for human physiology and diseaseThere exists a significant need to enhance and broaden the utility of this model with the development of new tools and strategiesNotablyantibodies are available for fewer thanof theknown zebrafish proteinsand the majority of t ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. The objective of this contract is to develop an HIV latent reservoir assay using a microwell array consumable.

    SBC: Cell Microsystems, Inc.            Topic: NIAID

    A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health

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