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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Develop predictive human cardiomyocyte-based all optical assay for cardiotoxicity

    SBC: Q-state Biosciences, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Develop predictive human cardiomyocyte based all optical assay for cardiotoxicity Cardiotoxicity is the leading cause of safety driven withdrawal a all stages and limitation of drug compounds The current cardiac safety paradigm nonclinical guidance ICH S B focuses on in vitro hERG assays which prove to be suboptimal in predicting a compoundandapos s cardioto ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Stem Cell Bioreactor for Cardiac Care

    SBC: Sentien Biotechnologies, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The goal of this Fast Track Phase I II SBIR is to test a novel extracorporeal system for delivering mesenchymal stem cell MSC secretions to treat acute myocardial infarction MI We will use the Sentien proprietary extracorporeal delivery system to treat swine subjected to a clinically relevant model of MI The project specific aims are Simulated blood ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. FAST TRACK: IND Enabling Studies for Oral Cancer

    SBC: PRIVO TECHNOLOGIES, LLC            Topic: 102

    DESCRIPTION provided by applicant According to the Oral Cancer OC Foundation oral and pharyngeal cancer will cause deaths this year in the US killing roughly one person per hour Currently cisplatin CIS is at the forefront of platinum based chemotherapeutics for treating OC However its efficacy is often hindered by its significant systemic toxicity as a resut of traditional bolus ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. High Performance Switched Reluctance Generator Controller

    SBC: QUALTECH SYSTEMS, INC.            Topic: A15087

    This proposal describes a method to reduce the acoustic noise and torque ripple of a switched-reluctance machine by solving a multi-objective optimization problem. The physical limitations of the machine, namely voltage and temperature, are used as constraints, and these are related to the objectives of noise and torque variation. Electrical, mechanical, and thermal models are used to form an anal ...

    SBIR Phase I 2015 Department of DefenseArmy
  5. Category-Theoretic Tool for Manufacturing-related Information Integration

    SBC: CATEGORICAL INFORMATICS, INC.            Topic: 9010173R

    Categorical theory has recently been successfully applied to translate information from one computer system to another. Researchers at MIT have developed a prototype software tool based on category theory for solving information-integration programs. The tool has successfully solved small-scale information-integration problems including a problem identified by NIST about enriching the manufacturin ...

    SBIR Phase I 2015 Department of CommerceNational Institute of Standards and Technology
  6. High Performance Accelerated Graph Programming Enabled by Julia

    SBC: Julia Computing, Inc.            Topic: SB152004

    Julia Computing seeks to significantly enhance visualization, data and graph analytics at high performance speeds to provide information for actionable intelligence to DoD and commercial sectors. This SBIR will leverage the Julia computing language's flexibility and modern architecture to exploit parallelism available through a range of modern accelerators including many core architectures (e.g. ...

    SBIR Phase I 2015 Department of DefenseDefense Advanced Research Projects Agency
  7. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: NIEHS

    DESCRIPTION provided by applicant The EPA maintains a Toxics Release Inventory of over toxic chemicals that are disposed or released from more than industrial sites in the United States The Department of Health and Human Services and USDA maintain a list of over select agents and toxins that pose a severe risk to both human animal and plant health These compounds represent only ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. ASTROCYTE ACTIVATION BY SMALL MOLECULE P2Y1 AGONISTS FOR TREATMENT OF TBI

    SBC: ASTROCYTE PHARMACEUTICALS INC.            Topic: 105

    DESCRIPTION provided by applicant Traumatic brain injuries TBI are an area of significant unmet need with no approved therapeutics and a national burden of $ billion annually Astrocyte Pharmaceuticals is developing a small molecule pharmaceutical agent that would be administered by intravenous injection by emergency responders or a medical professional within hours of injury to limit n ...

    STTR Phase I 2015 Department of Health and Human Services
  9. Development of a low-cost, portable autorefractor for the measuring of refractive errors in low-resource settings

    SBC: PlenOptika, Inc.            Topic: NEI

    DESCRIPTION provided by applicant andquot Development of a low cost extended range autorefractorandquot This project proposal seeks to develop technologies that will lower the cost of and increase the accessibility of refractive eye care especially in low resoure settings We propose to advance our previously developed low cost handheld device capable of automati ...

    SBIR Phase I 2015 Department of Health and Human Services
  10. A Structural Brain MRI Dementia Forecast Tool

    SBC: CORTICOMETRICS LLC            Topic: NIA

    DESCRIPTION provided by applicant Alzheimerandapos s disease AD the most common type of dementia is a devastating disease with no available treatment or prevention The current lifetime risk for a year old individual is estimated to be around Given current projections over million individuals will be diagnosed with Alzheimerandapos s disease by As the development of the ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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