Award Data

DESCRIPTION provided by applicant In the proposed study a novel approach which has already generated multiple commercial sales for SilcsBio LLC Site Identification by Ligand Competitive Saturation SILCS will be further developed to address customer requests and concerns around SILCS utility Successful commercial application of computational methods for ligand design require a platform th ...

DESCRIPTION provided by applicant Develop predictive human cardiomyocyte based all optical assay for cardiotoxicity Cardiotoxicity is the leading cause of safety driven withdrawal a all stages and limitation of drug compounds The current cardiac safety paradigm nonclinical guidance ICH S B focuses on in vitro hERG assays which prove to be suboptimal in predicting a compoundandapos s cardioto ...

DESCRIPTION provided by applicant The Specific Aim of this proposal is to test the feasibility of developing a catheter based indwelling biosensor for the real time continuous monitoring of chemotherapeutic blood levels of lung cancer patients A tool that continuously monitors blood drug levels in real time will enable an unprecedented understanding of an individual patientandapos s distinct ...

DESCRIPTION provided by applicant The goal of this Fast Track Phase I II SBIR is to test a novel extracorporeal system for delivering mesenchymal stem cell MSC secretions to treat acute myocardial infarction MI We will use the Sentien proprietary extracorporeal delivery system to treat swine subjected to a clinically relevant model of MI The project specific aims are Simulated blood ...

DESCRIPTION provided by applicant According to the Oral Cancer OC Foundation oral and pharyngeal cancer will cause deaths this year in the US killing roughly one person per hour Currently cisplatin CIS is at the forefront of platinum based chemotherapeutics for treating OC However its efficacy is often hindered by its significant systemic toxicity as a resut of traditional bolus ...

This proposal describes a method to reduce the acoustic noise and torque ripple of a switched-reluctance machine by solving a multi-objective optimization problem. The physical limitations of the machine, namely voltage and temperature, are used as constraints, and these are related to the objectives of noise and torque variation. Electrical, mechanical, and thermal models are used to form an anal ...

Categorical theory has recently been successfully applied to translate information from one computer system to another. Researchers at MIT have developed a prototype software tool based on category theory for solving information-integration programs. The tool has successfully solved small-scale information-integration problems including a problem identified by NIST about enriching the manufacturin ...

Julia Computing seeks to significantly enhance visualization, data and graph analytics at high performance speeds to provide information for actionable intelligence to DoD and commercial sectors. This SBIR will leverage the Julia computing language's flexibility and modern architecture to exploit parallelism available through a range of modern accelerators including many core architectures (e.g. ...

This award is for participation in the I-CORPS Program through DHS SBIR CRPP funds. Basic requirements include: Attend the initial seminar at the prescribed location (three to four days) Attend the closing lessons learned seminar seven weeks later at the identical location as the opening seminar Carry out one hundred face to face interviews with potential customers.

ABSTRACT: Our main objective in this project is to propose a novel Structured Sparse Priors for Target Recognition (SSPTR) system and to demonstrate that discriminative applications such as data clustering or target detection, tracking, and classification can be solved effectively and directly on the compressed measurement domain without the need to recover the original data. Our proposed sparse-r ...