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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ECM Bioscaffold for ASD Repair

    SBC: ACELL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase I proposal seeks support to evaluate the feasibility of developing an extracellular matrix (ECM) biologic scaffold as a repair device for atrial septal defects (ASD). ASDs are one of the most common forms of congenital heart disease and account for approximately 30-40% of all congenital heart defects seen in adults. Closure of an ASD can be performed ...

    SBIR Phase I 2006 Department of Health and Human Services
  2. Directed Differentiation of Embryonic Stem Cells using Phage Displayed Ligands

    SBC: OCATA THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The ability to culture human embryonic stem cells generated a great deal of excitement about their vast potential for treating a variety of human diseases such as diabetes, heart disease, neurological, retinal and skin disorders to name a few. Unlike adult stem cells, embryonic stem cells have indefinite growth potential and the potential to develop into any t ...

    STTR Phase I 2006 Department of Health and Human Services
  3. Clinical study of GMCI in Pancreatic Cancer

    SBC: ADVANTAGENE, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Pancreatic adenocarcinoma is the fourth leading cause of cancer deaths in the US; with less than one-year median survival, it accounts for approximately 30,000 diagnoses and deaths per year. Multimodality therapy, including surgery, radiation and chemotherapy, have not made a significant impact on the outcome and serve mostly as palliation. Thus, new treatment ...

    SBIR Phase I 2006 Department of Health and Human Services
  4. PET Detector for Cardiac Imaging of Small Animals

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Positron emission tomography (PET) of small animals is emerging as a very powerful tool for advancing our understanding of human diseases such as heart disease and cancer. Due to the small (sub-millimeter) feature sizes, dedicated, high resolution PET systems are required to obtain sufficiently detailed images of organs of interest. In particular, sub-millimete ...

    SBIR Phase I 2006 Department of Health and Human Services
  5. High Sensitivity Pesticide and Nerve Agent Detector

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): RMD Inc. proposes to develop direct reading, highly sensitive, reusable point sensors for detecting organophosphate and carbomate pesticide and nerve agent contamination in liquid and air. The sensors can be made for visual detection and handheld instrument readout using absorbance and fluorescence transduction modes, and will be suitable for unattended continu ...

    SBIR Phase I 2006 Department of Health and Human Services
  6. Low Cost Co Doped Scintillator for Medical CT

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Although CsI:TI is one of the most desirable scintillators for a broad range of medical and industrial diagnostics, it has never been applicable to X-ray computerized tomography (CT). Despite the otherwise superb properties of CsI, it suffers from a persistent afterglow that simply does not decay fast enough to provide rapid framing rates without unacceptable c ...

    SBIR Phase I 2006 Department of Health and Human Services
  7. HIGH RESOLUTION NUCLEAR CARDIAC IMAGING

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an image of the three dimensional distribution of a radionuclide in any slice through an organ under study in the body [Phelps]. These images allow investigation ...

    SBIR Phase I 2006 Department of Health and Human Services
  8. High Spatial Resolution Structured Plastic Scintillator

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a fast high spatial resolution scintillator for time-resolved neutron crystallography. Neutron crystallography compliments x-ray crystallography in its ability to precisely locate hydrogen atoms in protein molecules. The information on hydrogen location is important for monitoring protein dynamics (e.g. hydrogen-de ...

    SBIR Phase I 2006 Department of Health and Human Services
  9. High Resolution PET Detectors for Combined PET-MR Small Animal Imaging

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radiolabeled probes. Unfortunately, precise signal localization can be extremely difficult du ...

    SBIR Phase I 2006 Department of Health and Human Services
  10. Multibeam Healing for Laser Micromachining in Manufacturing

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): There is a considerable interest in using laser-manufacturing methods for medical applications due to their potential to reduce cost. In fact, the precision and low-force signature of lasers makes them very attractive alternatives to traditional machining methods for brittle materials such as lutetium oxyorthosilicate (LSO) and gadolinium oxyorthosilciate (GSO) ...

    SBIR Phase I 2006 Department of Health and Human Services

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