List

The topic (8.2.2R) requires the capability for enabling high sensitive/high precision measurements of calcium concentrates in seawater. The proposal aims to demonstrate the feasibility of a novel high sensitive nanosensor that can be used to determine very low concentrations of calcium in seawater in the presence of large backgrounds calcium concentration. The sensor approach will use the benefi ...

In this proposal, Physical Sciences Inc. (PSI) outlines the development of a system for remediating ammonia (NH3) produced in large confined animal feeding operations (CAFOs). The animal agricultural industry is coming under increased scrutiny due to the large volume of pollutants, in particular ammonia, produced in its operations. PSI's proposed remediation system for NH3 utilizes an adsorbe ...

Autism Spectrum Disorders (ASDs) are severe neurodevelopmental disabilities characterized by deficits in social and communication skills and the presence of restrictive, repetitive behaviors. For the 80 percent of individuals with ASDs who speak, prosody—the rhythm, stress, and intonation of speech—is among the most noticeable and chronic impairments. Prosodic speech deficits impede social int ...

The goal of this Phase 1 project is to identify changes in residual limb volume in amputees and to warn the user when these changes may lead to potential problems. One cause of residual limb pain in amputees is improper prosthetic socket fit, causing a range of mild to unbearable pressures. Residual limbs can change shape over long timeframes which can change the interface between the socket and s ...

The goal of this project is to provide real-time monitoring and data logging to help both the patient and clinician determine if and when a scoliosis brace is being worn effectively. Despite widespread use of bracing for treatment of scoliosis, its efficacy remains unproven. Studies have indicated that user compliance is a large factor in the efficacy of scoliosis brace treatment. Two factors comp ...

DESCRIPTION (provided by applicant): Alcoholic Liver Disease (ALD) remains a leading cause of death from liver disease in the U.S., and there is still no FDA-approved therapy. Abnormal cytokine metabolism is a major feature of ALD. Elevated serum concentrations of tumor necrosis factor (TNF-) and TNF--inducible proinflammatory cytokines/chemokines, such as IL-8 and IL-18 have been reported in pati ...

DESCRIPTION (provided by applicant): The goal of this project is to study and validate the tolerability of vaginally-administered PT-101, a novel low dose formulation of Tamoxifen Citrate for vaginal administration. PT-101 was designed to treat vulvovaginal atrophy (VVA), a condition associated with aging, menopause and breast cancer treatment. Estrogen loss is the primary cause of VVA, a conditio ...

DESCRIPTION (provided by applicant): This interdisciplinary project aims to develop an innovative rehabilitation technology for prevention of fall in elderly and more specifically elderl with diabetes by combining wearable sensor technology and virtual reality. Falls in the elderly are a major geriatric problem, with an estimated 30% of elderly adults over 65 years of age falling each year. [1-3] ...

DESCRIPTION (provided by applicant): Aquilus Pharmaceuticals, Inc. proposes to evaluate the effects of two novel matrix metalloproteinase (MMP) inhibitors in both the medial meniscal tear (MMT) and monoiodoacetate (MIA) rat models of osteoarthritis (OA) with pain read-outs. The goals for Phase I are to scale-up the synthesis of the allosteric, MMP-13 and dual active MMP-2/-9 inhibitors, determine ...

DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 38,000 confirmed and probable cases reported to the CDC in 2009. Spirochetes first establish infection in the skin and then disseminate to internal organs such as the heart, the joints, and the ...