Award Data

Abstract The overall goal of this proposal is to combine expertise and approaches from biomedical engineering and critical care medicine to design a universal system to acquire, record and transmit physiological signals from bedside monitored patients. Patient monitors generate over a million datapoints of information per hour, however, only a tiny fraction of those data are transmitted or recorde ...

PROJECT SUMMARY ALS is a devastating neurodegenerative disease with two FDA-approved therapies that can prolong a patient’s lifespan by only a few months. Thus, an effective therapeutic to treat ALS is needed. ALS can arise sporadically or through inherited mutations in one or a combination of several genes. The heterogeneity of ALS makes it difficult to create a therapeutic that can effectively ...

Project Summary/AbstractThe idiosyncrasies of the human brain require that individualized mapping of functional regions be performed before surgical interventions for cancer or epilepsy. The success of this mapping procedure has direct effects on surgical outcomes and preserving cognitive and sensory function post-surgery. Current gold standard procedures for pre-surgical mapping are invasive, tim ...

ABSTRACT Rgenta has developed a robust, innovative, target and lead discovery platform that has identified small molecules that can lower the levels of HTT through a novel mechanism-of-action in RNA-targeting. In this Phase I SBIR project, we aim to develop first-in-class drug candidate compounds for HTT lowering as a new therapeutic approach for treating HD. Our Phase I SBIR proposal has three ai ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop safe and affordable COVID-19 vaccination technology, with broader utility in preventing other types of outbreak in the future. This nov

Project Summary: Narcotic use in pain management of underserved minority populations and minority United States veterans has played a major role in the ongoing opioid crisis. According to the NIH, veterans are more susceptible to opioid addiction and are 40% more likely to suffer from severe chronic joint pain then non-veterans. Over the next decade, the percentage of minority veterans will increa ...

Project Summary/Abstract The abuse of opioids is a serious national crisis that affects public health as well as social and economic welfare. A 2018 report from the Centers for Disease Control and Prevention (CDC) shows that every day, 128 people in the United States die from opioid overdose. Synthetic opioids (e.g. fentanyl) have become the leading cause of drug-related deaths in recent years. Th ...

Project Summary/Abstract Wearable sensor for opioids detection based on electrochemical sensor arrayintegrated with Bluetooth deviceIn this Phase I project, we will develop the prototype of a wearable device, as a forearm bracelet, for rapid, on-site opioid intake monitoring and alerting. We will demonstrate the feasibility of this approach by fabricating an electrochemical sensor array, sweat sti ...

Project Summary/Abstract This Administrative Supplement proposes the participation of a 3-member team from the Center for Progressive Recovery, LLC (CPR) in the Innovation Corps (I-Corps™), an intensive, 8-week program focused on developing a successful commercialization plan and business model for technology-driven start-ups funded by NIH’s SBIR Phase I mechanism. The program would entail tra ...

The broader impact/commercial potential of this Small Business Innovation Research Phase I project is the development of an environmentally neutral product for control of red imported fire ants (RIFA), aggressive pests that occur in high densities and are