Award Data

DESCRIPTION (provided by applicant): Cardiac failure is the, largest single cause of mortality in the United States today. With an increase in the use of long-term cardiac assist devices, there is also a need for the short-term "bridge to recovery" application. This application is intended to provide a low-cost temporary support for patients whose heart is capable of recovering. This "patient scr ...

DESCRIPTION (provided by applicant): Current HIV-1 therapy suffers from inadequate viral load suppression due to poor compliance, resistance, and interactions with other drugs and can lead to spread of drug-resistant strains. The current drug cocktails need to include inhibitors of viral components that are likely to slow resistance development. One such target is the HIV-1 capsid, an essential vi ...

DESCRIPTION (provided by applicant): This Phase I SBIR application is presented by Aeris Therapeutics, Inc. of Woburn, MA. It will examine the feasibility of using a novel enzyme based-system to produce safe, clinically-effective pleurodesis for treatment of malignant pleural effusions. Preliminary data, summarized in this application, suggest that an enzymatic system has the potential for bei ...

DESCRIPTION (provided by applicant): The analysis of components in human breath is a powerful non-invasive technique for the diagnosis and monitoring of asthma, cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The presence of elevated levels of nitric oxide (NO), carbon monoxide (CO), and ethane (C2H6) in the breath have been identified as biomarkers of these diseases, wh ...

DESCRIPTION (provided by applicant): Real-time or dynamic radiographic imaging (fluoroscopy) provides vital information concerning internal organ structure, flow of contrast agents and in-vivo instrument positioning. Fluoroscopy is a very important modality for cardiac and vascular imaging including subtraction angiography where it is used for locating and evaluating cardiac structures, major v ...

DESCRIPTION (provided by applicant): Radiation Monitoring Devices (RMD) proposes to develop a new dental x-ray imager that will have all the advantages of a digital technology and retain the most desirable aspects of image quality that film emulsions provide. The device will be a blend of two technologies - silicon based imaging arrays and semiconductor x-ray conversion layers. RMD will work on ta ...

DESCRIPTION (provided by applicant): Information on the structure and function of proteins is important for unveiling the biological processes taking place on a molecular level. X-ray crystallography has been successful in determining protein structure, however is not well suited for analyzing hydrogen atoms and water molecules. It has been shown that the thermal neutrons are a far better tool for ...

DESCRIPTION (provided by applicant): Magnetocardiography (MCG) has been shown to offer powerful disease detection and diagnostic capabilities in both humans and animals not readily achieved with standard ECG and echocardiography, including the ability to map ischemic regions in the heart, and monitor arrhythmia. Fetal magnetocardiography (fMCG) has been successfully employed for the non-invasive s ...

DESCRIPTION (provided by applicant): The complement component C5 is common to all three pathways of complement activation. Its involvement in the pathogenesis of asthma is controversial. We have recently shown that the intrapulmonary activation of C5 is critical in animal models of asthma (manuscript, submitted). Our data demonstrated that C5 inhibition has profound effects at all the critical poi ...

DESCRIPTION (provided by applicant): The overall goal of this project is to produce large amounts of high-quality lead-203 on a routine basis, at reasonable prices to support cancer research and approved drug products. It is expected that Pb-203 will be the imaging agent for therapies using lead-212. Over the last five years researchers have been obtaining promising results in pre-clinical studies ...