Award Data

THE OBJECTIVE OF THIS PROGRAM IS TO DESIGN AND BUILD A STAPLER FOR PERFORMING END-TO-END AND END-TO-SIDE ANASTOMOSES ON MEDIUM TO LARGE VESSELS, AND FOR REPAIRING BLOOD VESSELS AND VASCULAR ANEURYSMS, AND TO DEVELOP A SURGICAL PROTOCOL FOR ITS USE. THE METHOD PROPOSED USES A SPECIAL STAPLER AND CONFIGURATION OF STAPLES WHICH MINIMIZESBLOOD CONTACT WITH THE STAPLES, DOES NOT RESTRICT THE FLOW OF BL ...

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MANY DISABLED INDIVIDUALS ARE CURRENTLY BENEFITTING FROM THEFIELD OF THERAPY CALLED THERAPEUTIC RECREATION. EVERY MAJORREHABILITATION CENTER HAS A SEPARATE AND GROWING RECREATION THERAPY DEPARTMENT AS THIS FIELD OF THERAPY GAINS RECOGNI- HAVE SPECIAL EQUIPMENT IN ORDER TO PARTICIPATE. THE DIFFICULTY IN FINDING SUCH EQUIPMENT IS PERSONALLY UNDERSTOOD BY THE PRINCIPAL INVESTIGATOR, WHO WAS PARALYZED ...

THERE IS A NEED FOR A CORONARY-ARTERY DISEASE SCREENING METHOD NOT REQUIRING THE RISK OF AN ARTERIAL CATHETER. DIGITAL-SUBTRACTION RADIOGRAPHS USING IODINE-K-EDGE SUBTRACTION SUFFER FROM LOW X-RAY INTENSITIES AND REQUIRE LARGE IODINE CONCENTRATIONS PRECLUDING NON-INVASIVE TECHNIQUES. BRIGHTER X-RAY SOURCES ARE NEEDED. WE PROPOSE TO CONDUCT AN EVALUATION OF METAL OXIDES AS CHARACTERISTIC-LINE X-RAY ...

THE HISPANIC HEALTH AND NUTRITION EXAMINATION SURVEY (HHANES) CONTAINS A WEALTH OF INFORMATION FOR THE CANCER RESEARCH PROFESSIONAL. THE UTILITY OF THIS DATA BASE CAN BE SIGNIFICANTLY IMPROVED BY PROVIDING A SIMPLE USER INTERFACE SOFTWARE PACKAGE THAT CONVERTS THE DATA INTO USABLE INPUT FOR A COMMERCIAL RELATIONAL DATA BASE MANAGEMENT SYSTEM (RDBMS). ONCE THE HHANES DATA HAS BEEN CONVERTED INTO TH ...

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TUMOR NECROSIS FACTOR (TNF) IS A 17,000-DALTON POLYPEPTIDE SECRETED BY MACROPHAGES WHICH HAS ANTITUMOR CYTOLYTIC ACTIVITY. TNF DOES NOT APPEAR TO AFFECT NORMAL CELLS AND HAS BEEN SHOWN REPEATEDLY TO EITHER KILL OR PREVENT THE GROWTH OF TUMOR CELLS IN BOTH IN VITRO AND IN VIVO MODEL SYSTEMS. TNF IS THOUGHT TO EXERT ITS EFFECT THROUGH A PROCESS INITIATED BY THE BINDING OF TNF TO SPECIFIC CELL SURFAC ...

INCREASING THE THERAPEUTIC EFFICACY OF MANY ANTICANCER DRUGS.THE LONG-RANGE GOAL OF THIS PROPOSAL IS TO DEVELOP AN IN VITRO TEST TO IMPROVE SELECTIONS OF THERAPIES FOR INDIVIDUAL BREAST CANCER PATIENTS BY PREDICTING RESPONSE TO METHOTREXATE. EXISTING ASSAYS FOR BREAST CANCER CELLS CANNOT DETERMINE METHOTREXATE SENSITIVITY BECAUSE OF REQUIREMENTS FOR FEEDER LAYERS AND MEDIUM COMPONENTS WHICH CAN RE ...

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IMMUNOLOGICAL AND DNA HYBRIDIZATION ASSAYS WHICH EMPLOY SPECIFIC ANTIBODY AND DNA PROBES ARE PROVING TO BE VERY VALUABLE IN THE IDENTIFICATION OF PATHOGENS AND IN THE DIAGNOSIS OF GENETIC DISEASES. THE OBJECTIVE OF THIS PROJECT IS TO IMPROVE THE SENSITIVITY, SAFETY, AND CONVENIENCE OF DIAGNOSTIC TESTS BY DEVELOPING A NONRADIOACTIVE, LUCIFERASE BASED PROBE TECHNIQUE. TO EVALUATE THE USEFULNESS OF L ...