Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. An ODNP Probe to Study Hydration Dynamics in Membrane Protein

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: 400

    DESCRIPTION provided by applicant The proposed research focuses on the development of a cost effect turn key probe for liquid state Overhauser Dynamic Nuclear Polarization ODNP spectroscopy to study the site specific translational dynamics of water molecules located at the interface of bio macromolecules such as membrane proteins It will allow researchers to readily perform ODNP experiments ...

    SBIR Phase I 2015 Department of Health and Human Services
  2. TDP-43 aggregation inhibitors for the treatment of ALS

    SBC: Aquinnah Pharmaceuticals Inc.            Topic: 105

    DESCRIPTION provided by applicant There is currently no therapy for Amyotrophic Lateral Sclerosis ALS which is a universally fatal neurodegenerative disease that afflicts over out of every individuals Protein aggregation has been implicated as a primary driving force in ALS and multiple other neurodegenerative illnesses TDP is the principle component of the protein aggregates i ...

    SBIR Phase I 2015 Department of Health and Human Services
  3. Development of a low-cost, portable autorefractor for the measuring of refractive errors in low-resource settings

    SBC: PlenOptika, Inc.            Topic: NEI

    DESCRIPTION provided by applicant andquot Development of a low cost extended range autorefractorandquot This project proposal seeks to develop technologies that will lower the cost of and increase the accessibility of refractive eye care especially in low resoure settings We propose to advance our previously developed low cost handheld device capable of automati ...

    SBIR Phase I 2015 Department of Health and Human Services
  4. ASTROCYTE ACTIVATION BY SMALL MOLECULE P2Y1 AGONISTS FOR TREATMENT OF TBI

    SBC: ASTROCYTE PHARMACEUTICALS INC.            Topic: 105

    DESCRIPTION provided by applicant Traumatic brain injuries TBI are an area of significant unmet need with no approved therapeutics and a national burden of $ billion annually Astrocyte Pharmaceuticals is developing a small molecule pharmaceutical agent that would be administered by intravenous injection by emergency responders or a medical professional within hours of injury to limit n ...

    STTR Phase I 2015 Department of Health and Human Services
  5. Motor Unit Drive (MU Drive) for Prosthetic Control

    SBC: ALTEC Inc            Topic: 103

    DESCRIPTION provided by applicant The proposed work will develop a non invasive interface MU Drive c able to extract the incremental motor unit MU firings during voluntary muscle contractions and use this information as control sources to drive upper limb prostheses for amputees Motor units provide high levels of incremental control for intact limbs and therefore have the potential of p ...

    SBIR Phase I 2015 Department of Health and Human Services
  6. GPCR antagonists as anti-Ebola virus entry inhibitors

    SBC: MICROBIOTIX, INC.            Topic: R

    DESCRIPTION provided by applicant Ebola EBOV and Marburg MARV viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as biosafety level agents Currently there is no effective vaccine or therapeutic treatment against f ...

    STTR Phase I 2015 Department of Health and Human Services
  7. Preventing and Reducing HAND by Using New BDNF Nanoprobes

    SBC: ExQor Technologies Inc            Topic: 105

    DESCRIPTION provided by applicant Human immunodeficiency virus HIV associated neurocognitive disorder HAND represents a major chronic health problem in the US and abroad MRI studies of HAND consistently show a decrease in the size of the hippocampus and other brain structures associated with learning and memory Advances in treatment of HAND have been made by administering brain derived ne ...

    SBIR Phase I 2015 Department of Health and Human Services
  8. Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody

    SBC: GEOVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The proposed project Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody tests the directed lineage D L approach to HIV vaccination using clade C immunogens With a D L vaccine a series of progressively evolved Env immunogens are used to drive development of a broadly neutralizing antibody bnAb response which is important because ...

    SBIR Phase I 2015 Department of Health and Human Services
  9. Antibiotic potentiators maximizing the formation of open- channel OprF-type outer membrane porins

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The overall goal of this project is to address the critical medical need for agents to combat antibacterial drug resistance by a novel approach of potentiating drug influx in Gram negative non fermenters such as Pseudomonas aeruginosa and Acinetobacter baumannii These species exhibit intrinsic drug resistance due to the combined effects of a poorly permeable o ...

    SBIR Phase I 2015 Department of Health and Human Services
  10. Development of a robust, vector-free intracellular delivery platform for immune cells

    SBC: SQZ BIOTECHNOLOGIES COMPANY            Topic: 300

    DESCRIPTION provided by applicant During the past decades immunologists have deciphered many of the mechanisms by which the mammalian immune system either combats or mediates a host of diseases and clinicians are beginning to translate these insights into novel immunotherapies However current technologies are often inadequate to promote further progress in our understanding of cellular and ...

    SBIR Phase I 2015 Department of Health and Human Services
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