List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Genome Mining the Full Diversity of the Actinomycete Biosynthetic Universe for Neomorph Antibiotic Discovery

    SBC: WARP DRIVE BIO, LLC            Topic: NIAID

    ABSTRACT To combat multidrug resistant bacterial infections novel classes of antibiotics with new mechanisms of action are desperately required Genome mining for novel natural products is quickly replacing traditional approaches to antibiotic discovery Warp Drive Bio has sequenced over actinomycete strain genomes from diverse sources worldwide and our proprietary genomic database conta ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Selection of a device for intranasal administration of a mucosal vaccine for HSV

    SBC: Biomedical Research Models, Inc.            Topic: R

    Globally an estimated of the human population is infected with HSV including andgt of the U S adult population Genital herpes is associated with an increased risk of HIV acquisition and transmission of HSV infection can cause neonatal herpes with high infant mortality HSV infection in the adult population has increased substantially in the past two decades despite the availabil ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. A Rapid Low Cost Point of Care Diagnostic for detection of Zika virus RNA

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    ABSTRACT Zika virus ZIKV has rapidly emerged and spread through South and Central America the Caribbean and Puerto Rico since its last outbreak in Micronesia in Transmitted by the mosquito Aedes sp its forecasted spread will have a major impact on the Southeast U S Most ZIKV infections remain asymptomatic or present with non specific rash and fever therefore they have been difficult ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Harnessing Genomic Information to Engineer Combinatorial Biosynthesis of a Large Polyketide Natural Products Library

    SBC: WARP DRIVE BIO, LLC            Topic: NIAID

    Abstract Natural products have outstanding pharmaceutical pedigree approximately of FDA approved small molecule drugs are derived from plant bacterial or fungal sources To discover new natural products Warp Drive Bio has assembled an enormous proprietary and searchable database of microbial genomes and biosynthetic gene clusters To date our database comprises genomes sequenced ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf Activation Pathway

    SBC: Pathways Bioscience, LLC            Topic: NIA

    The average lifespan and the number of older individuals is increasing in the US but because age is a primary risk factor for most chronic disease there is an accompanying increase in the burden of chronic disease in the US Diet and lifestyle choices including dietary supplementation may be useful approaches to slowing the aging process and increasing healthspan and also may be the best stra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. "Modulation of Immune Checkpoints by Self Deliverable RNAi for Adoptive Cell Transfer"

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 102

    Two of the most promising approaches to cancer immunotherapy are immune checkpoint blockade by monoclonal antibodies and the adoptive transfer of immune cells The recent successes in treating melanoma with anti PD and anti CTLA antibodies as well as the extremely successful application of T cells engineered to express the CAR receptor targeting CD to treat B cell lymphomas initiated a waterfal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Optical Dosimeter guided Photodynamic Therapy

    SBC: Physical Sciences Inc.            Topic: 102

    Photodynamic Therapy PDT is a promising modality for cancer treatment Oxygen molecules in the metastable singlet delta state O are believed to be the species that destroys cancerous cells during PDT Despite the benefit of targeted PDT that kills tumors selectively with minimum effect on surrounding healthy tissues at the present time it is difficult if not impossible to predict the res ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Improving delivery of paclitaxel to ovarian cancer via expansile nanoparticles

    SBC: IONIC PHARMACEUTICALS            Topic: 102

    ABSTRACT A primary challenge in ovarian cancer is preventing tumor recurrence in patients following a resection debulking procedure year survival rate andlt Intraperitoneal IP administration of chemotherapy most notably paclitaxel can improve patient outcomes and prevent local tumor recurrence the principal deterrent to long term survival However despite these modest improvement ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Immuno-PCR for Detection of Toxins in Medicinal Cannabis

    SBC: COURTAGEN LIFE SCIENCES, INC.            Topic: NIDA

    Abstract The overall goal of this project is to develop an optimized assay design and development process to permit the rapid implementation of sensitive bead based immuno PCR assays for the detection of the major bacterial and fungal toxins that are produced by common contaminants of medicinal cannabis The assay process will be developed and validated in Phase I focusing on one important small ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. High sensitive and specific Point of use lateral flow strip for on site test of cannabis intoxication

    SBC: Vitan-Biotech LLC            Topic: NIDA

    Project Summary Marijuana e g cannabis is the most frequently detected drug of abuse Cannabis abuse has a substantial impact on public safety as driving under the influence of cannabis will impair driving skill and the marijuana use in the workplace will increase the risk of adverse events and the loss of productivity With the recent wave of legalization of marijuana use in numerous states ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government