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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Dermal Medical Countermeasures for Chemical Weapons Exposure

    SBC: Nano Terra, Inc.            Topic: CBD161003

    Chemical warfare agents (CWAs), such as nerve agents and mustard agents, pose serious threats to our warfighters and civilians. Current formulations of dermal medical countermeasures to CWAs can be absorbed through the skin causing systemic toxicities to the patients. These formulations are limited by the FDA for use only in small area of intact skin, which severely restricts the usefulness of the ...

    SBIR Phase I 2017 Department of DefenseOffice for Chemical and Biological Defense
  2. Development of small molecule TLR5 inhibitors for rheumatoid arthritis therapy

    SBC: MICROBIOTIX, INC.            Topic: NIA

    AbstractApproximatelymillion Americans have rheumatoid arthritisRAwhich is one of the most common chronic autoimmune disorders in the older populationThere is no cure for RAand up toof patients do not respond to current therapiesAs a resultdisease progression leads to joint destruction and severe disability in the elderlyThereforethe identification of a novel therapeutic strategy used alone or in ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Inhibitors of Pseudomonas aeruginosa efflux pumps to combat multi-drug resistance

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    Abstract Multi drug resistanceMDRin Gram negative pathogensincluding Pseudomonas aeruginosaposes a significant threat for effective treatment of infections caused by these organismsA major component in the development of the MDR phenotype in Paeruginosa is overexpression of the Resistance Nodulation DevelopmentRNDfamily efflux pumpswhich pump antibacterial agents and biocides out of the celland ar ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. An Implantable and High-Density, Multiplexed Micro-ECoG System

    SBC: MICRO-LEADS INC            Topic: 105

    DescriptionThe mechanisms underlying brain functionssuch as perceptionmotor controllearning and memoryin health and disease result from the coordinated responses of neurons distributed across multiple brain regionsHoweverconventional electrode technologies have not scaled to capture this networked activityResearchers are forced to compromise between low resolution over large areas of the brain or ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Screening for rAAV transduction enhancers

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    ABSTRACT Recombinant adeno associated virusrAAVis a promising gene delivery vector for therapeutic and vaccine applicationsbut its low transduction efficacy currently limits its utilityThe primary reasons for low transduction efficacy are as followsiinefficient trafficking of the rAAV genome to the nucleusiiinefficient host cell mediated synthesis of double stranded DNA from the single stranded ge ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Platelet Bioreactor for Treatment of Radiation-Induced Thrombocytopenia

    SBC: PLATELET BIOGENESIS, INC            Topic: R

    Platelet Biogenesis is developing a microfluidic bioreactor that reproduces key features of adult bone marrowphysiological microenvironmentto produce human plateletsPLTsPLTs are thebandaidsof the bloodstreamresponsible for clot formation and blood vessel repairLow PLT count is a significant consequence of a radiation accident or deliberate nuclear attackfor which PLTs are a critical first line the ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Selection of a device for intranasal administration of a mucosal vaccine for HSV

    SBC: Biomedical Research Models, Inc.            Topic: R

    Globally an estimated of the human population is infected with HSV including andgt of the U S adult population Genital herpes is associated with an increased risk of HIV acquisition and transmission of HSV infection can cause neonatal herpes with high infant mortality HSV infection in the adult population has increased substantially in the past two decades despite the availabil ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Improving access to vision correction for health disparity populations with the QuickSee: an accurate, low-cost, easy-to-use objective refractor

    SBC: PLENOPTIKA, INC.            Topic: NIBIB

    Summary The principal goal of this proposal is to increase the accuracy and precision of a low cost autorefraction device called the QuickSeein order to improve access to refractive eye care for underserved populationsPoor vision due to a lack of eyeglasses is highly prevalent in low resource settings throughout the world and significantly reduces quality of lifeeducationand productivityThe existi ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Drug eluting Brachytherapy Implants for Chemo radiation Therapy

    SBC: TheraNano LLC            Topic: 102

    Prostate cancer PCa is the second leading cause of cancer death in American men with deaths and new cases estimated in the US in Radiation therapy is one of the standard therapies for high and intermediate risk patients and is a non surgical therapy option for low risk patients A combined chemo radiation therapy CRT approach has been shown in several trials to improve s ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Management of bioburden and tissue regeneration in diabetic wounds using engineered matrices

    SBC: GEL4MED, INC.            Topic: 300

    The goal of this Phase I SBIR proposal is to demonstrate the feasibility of an inherently broad spectrum antimicrobial tissue scaffolding matrix capable of eliminating infecting bacterial pathogens and improve wound closure in diabetics Delayed non healing diabetic wound is responsible for about annual non traumatic lower limb amputations in the US Microbial infections further complica ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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