Award Data

Abstract Alcohol dependence affects at leastof the US populationwith a financial cost in excess of $BnPrevention of relapse in patients attempting to reduce alcohol consumption is a major therapeutic targetbut current treatments are ineffectiveand there is an urgent need for new medicationsMajor factors in causing relapse include the protracted symptoms of withdrawal from alcoholwhich are relieved ...

Adjunctive antithrombotic treatment with dual antiplatelet therapyaspirinP Yantagonistplus anticoagulantheparin or bivalirudinis a guideline mandated for percutaneous coronaryinterventionPCIpatientsDespite aggressive antithrombotic therapyhowevermyocardialperfusion after PCI remains inadequate in many patientsReocclusion from recurrent thrombosiscontinues to occurand dose limiting bleeding occurs ...

Chemical warfare agents (CWAs), such as nerve agents and mustard agents, pose serious threats to our warfighters and civilians. Current formulations of dermal medical countermeasures to CWAs can be absorbed through the skin causing systemic toxicities to the patients. These formulations are limited by the FDA for use only in small area of intact skin, which severely restricts the usefulness of the ...

AbstractApproximatelymillion Americans have rheumatoid arthritisRAwhich is one of the most common chronic autoimmune disorders in the older populationThere is no cure for RAand up toof patients do not respond to current therapiesAs a resultdisease progression leads to joint destruction and severe disability in the elderlyThereforethe identification of a novel therapeutic strategy used alone or in ...

Abstract Multi drug resistanceMDRin Gram negative pathogensincluding Pseudomonas aeruginosaposes a significant threat for effective treatment of infections caused by these organismsA major component in the development of the MDR phenotype in Paeruginosa is overexpression of the Resistance Nodulation DevelopmentRNDfamily efflux pumpswhich pump antibacterial agents and biocides out of the celland ar ...

DescriptionThe mechanisms underlying brain functionssuch as perceptionmotor controllearning and memoryin health and disease result from the coordinated responses of neurons distributed across multiple brain regionsHoweverconventional electrode technologies have not scaled to capture this networked activityResearchers are forced to compromise between low resolution over large areas of the brain or ...

ABSTRACT Recombinant adeno associated virusrAAVis a promising gene delivery vector for therapeutic and vaccine applicationsbut its low transduction efficacy currently limits its utilityThe primary reasons for low transduction efficacy are as followsiinefficient trafficking of the rAAV genome to the nucleusiiinefficient host cell mediated synthesis of double stranded DNA from the single stranded ge ...

Project Abstract PGXL Technologies is developing novel urine based tests for detecting obstructive sleep apnea OSA in children Obstructive sleep apnea OSA is a disorder giving rise to behavioral and learning problems including misdiagnoses as attention deficit hyperactivity disorder ADHD in children The CDC estimates the prevalence of pediatric OSA in the US at around million An ...

Platelet Biogenesis is developing a microfluidic bioreactor that reproduces key features of adult bone marrowphysiological microenvironmentto produce human plateletsPLTsPLTs are thebandaidsof the bloodstreamresponsible for clot formation and blood vessel repairLow PLT count is a significant consequence of a radiation accident or deliberate nuclear attackfor which PLTs are a critical first line the ...

Globally an estimated of the human population is infected with HSV including andgt of the U S adult population Genital herpes is associated with an increased risk of HIV acquisition and transmission of HSV infection can cause neonatal herpes with high infant mortality HSV infection in the adult population has increased substantially in the past two decades despite the availabil ...