Award Data

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is the possibility to revolutionize the treatment of cancer through more sensitive and specific cancer biomarker detection. 1.66 million Americans were diagnosed with cancer in 2014 alone, of which 585,720 died. The sum of all health care costs in 2011 for cancer in the US was $88.7 billion. ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is the development of technology for use of sulfide mining waste streams as a novel energy source for the production of chemicals from CO2. Sulfide mining wastes pose a serious, perpetual environmental risk, and are continuously generated as by-products of mining operations. The sulfide minerals in mi ...

This STTR Phase I project aims to establish the viability of a drug delivery platform that employs an engineered strain of Staphylococcus (S.) epidermidis, a common skin commensal bacterium, that can secrete therapeutic proteins of interest for the ultimate goal of treating skin disease. An ointment with an inoculum of such bacteria could be infrequently applied to skin, providing constant, low-co ...

Abstract Hepatocellular carcinoma HCC is a disease of growing incidence globally including in the US by per year With the recent success of anti viral therapies the etiology of HCC in the American population is projected to shift from viral HBV HCV hepatitis to primarily fatty liver disease in the near future Currently only one effective systemic therapy has been developed for HCC ...

PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...

Coronary artery disease remains the leading cause of death in the United States Platelets play an important role in the pathogenesis of acute coronary syndrome ACS as platelet activation aggregation and secretion are key components of arterial thrombus formation Despite dual anti platelet therapy for ACS and percutaneous coronary interventions PCI many patients sustain a high incidence u ...

Project Summary Abstract Radiation therapy is one of the primary therapeutic techniques for treating cancer Nearly two thirds of all cancer patients will receive radiation therapy during their illness with an average of radiation treatment episodes Although largely effective radiation therapy like other forms of cancer treatment has difficulty killing hypoxic regions within solid tumors ...

This SBIR Phase I project will demonstrate the feasibility of producing ophthalmic lenses utilizing a low cost optical printer that will enable the fabrication of superior quality lenses with a low cost optical printer. The result is development of a business model where an eye exam is administered, prescription lenses are printed and glasses assembled and dispensed in a single visit. Upon complet ...

Neutron-sensitive microchannel Plates (MCPs) are now providing state-of-the-art user-based, high spatial resolution neutron imaging systems at several US government neutron research facilities as well as university research reactors. Using enriched 10B, thermalized neutron detection efficiencies exceeding 50% have been demonstrated, and cold neutron detection efficiencies of up to 70% have been do ...

Existing research and commercial software that apply the Finite Element Method to solve the equations of classical continuum mechanics have received widespread acceptance for structural analysis of traditional macroscale materials. Challenges persist in the modeling of complex phenomena in new advanced materials with heterogeneous structure. Such materials can revolutionize the aerospace and autom ...