Award Data

Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

The goal of this Proposal is treatment of hemorrhage in SOCOM canines using a novel hemoglobin resuscitation fluid with oxygen carrying and plasma expansion properties (VIR-VET, a product of VirTech Bio). VIR-VET is designed to provide immediate hemodynamic stability and oxygenation to injured canines with blood loss. The product has advantages over traditional military fluid therapies: 1) As cell ...

Multi-Purpose Canines (MPCs) are an integral aspect of the US military. The continued expansion and use of these indispensable force multipliers in an intense, ever-changing and complex battlefield requires enhancing their innate capabilities in a timely manner. Additionally, canines have a relatively short life span, and considering the substantial training period that MPCs must undergo, their ef ...

Triton Systems, Inc. proposes to develop a High Altitude Low Opening (HALO) parachute canopy with a single surface providing lift capability that leverages novel parachute design techniques and materials technology. The result is decreased weight, bulk, and maintenance resource burdens while achieving increased performance levels.

Organizations face two existential challenges: to anticipate and create surprise. Inefficiency and ineffectiveness are inevitable outcomes of the ensuing struggle. To mitigate these outcomes, organizations increasingly seek external help and guidance. However, the rush for such assistance betrays missed opportunity. Embedded knowledge and self-actualization among members remain largely untapped re ...

As organizations grow in size and complexity, it is only natural that inefficiencies exist. One of the challenges faced by organizations is the information needed to identify, characterize, and resolve these inefficiencies is located in different stovepipes and may be biased based on a variety of factors. Both crowdsourcing and human computation research and design thinking practices have develope ...

One-size-fits-all approaches to physical fitness are characterized by extreme limitations. When not individually-tailored, workouts can be ineffective or worse: so strenuous that they lead to injuries. Advances in wearable sensors allow individuals to capture personalized data related to their own physical fitness (e.g., heart rate, step count). Unfortunately, with such an abundance of physiologic ...

Marine physical fitness is a core element of force readiness: toward an end state of a healthy and fit force able to better answer the call in any clime and place (ALMARS 022/116). Marine physical training programs must be tailored to individuals in order to maximize the physical potential of every Marine. To meet this need, Charles River Analytics proposes to design and demonstrate a prototype sy ...

The objective of this SBIR program is to improve operational performance of US Army missile systems by enhancing position, navigation, and timing (PNT) for operation in GPS contested environments. The PNT system for the missile platforms will also require the system to be ruggedized to withstand shock during launch and operation with speeds spanning many mach. Mayflower proposes to develop and dem ...

This STTR Phase I project will undertake the development of iron coordination complexes as alternatives for gadolinium contrast agents which are currently used in clinical MRI diagnostic exams. New MRI contrast agents are needed to serve the segment of the population who cannot tolerate Gd(III) agents. This includes patients with kidney disease and those who have frequent MRI scans and may accumul ...